利培酮联合小剂量氯氮平治疗男性难治性精神分裂症

目的探索利培酮联合小剂量氧氮平治疗男性难治性精神分裂症的疗效对比，为临床用药提供依据。方法40例男性难治性精神分裂症患者随机分为研究组和对照组，分别用利培酮联合小剂量氟氮平（21例）、氯氮平（19例）治疗。分别运用BPRS及TESS来观察疗效及副作用。结果研究组治疗八周末BPRS总分明显低干对照组（P〈0．05），两组TESS总分差异无统计学意义（P〉o．os）。结论利培酮联合小剂量氯氮治疗男性难治性精神分裂症缩短治疗反应期且疗效可靠。

Risperidone and low dose Clozapine combination for the treament of male refractory schizophrenia

OBJECTIVE To explore the curative effect and side effect of Risperidone and low dose Clozapine combination for the treament of male refractory schizophrenia,to provide the basis for clinical medication.METHODS The male refractory schizophrenia number of 40 was random to separate the group of study and the control group,the male refractory schizophrenia number of 21 was treated by Risperidone and low dose Clozapine,the male refractory Schizophrenia number of 19 was treated by Clozapine alone.The curative effect and side effect was differently observed by BPRS and TESS.RESULTS The BPRS total scores of the study group were obviously lower than the control group at the end of the eight-week treatment,especially at the end of four,week treatment.The tess total scores between two groups had no significant difference(P>0.05).CONCLUSION The combination of Risperidone and low dose Clozapine produced a shortening of the treatment response latency,and the curative effect is relibal.