| BRAF及其信号通路相关蛋白在甲状腺乳头状癌中表达及意义 |
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| 引用本文： | 彭思丹,邹琼燕,易文君. BRAF及其信号通路相关蛋白在甲状腺乳头状癌中表达及意义[J]. 实用预防医学, 2011, 18(8): 1397-1399 |
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| 作者姓名： | 彭思丹 邹琼燕 易文君 |
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| 作者单位： | 中南大学湘雅二医院,湖南,长沙,410011 |
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| 摘 要： | 目的研究BRAF基因及其信号通路MEK/ERK与甲状腺乳头状癌发生的相关性及其部分作用机制。方法收集73例散发的甲状腺乳头状癌患者及16例同期甲状腺瘤患者（对照组）的临床资料及标本,采用免疫组织化学法检测两组标本组织中的RAS、BRAF、MEK和ERK蛋白表达状况。结果 RAS、BRAF、pMEK和pERK表达水平在甲状腺乳头状癌组都明显高于甲状腺瘤组（P〈0.05或P〈0.01）。结论 RAS、BRAF、pMEK及pERK可能与甲状腺乳头状癌发生相关。BRAF可能通过激活MEK/ERK信号通路而发挥其生物作用。
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| 关 键 词： | BRAF RAS MEK/ERK通路 甲状腺乳头状癌 |
Expression and Significance of BRAF and Its Signal Pathway in Papillary Thyroid Cancer |
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| PENG Si-dan,ZOU Qiong-yan,YI Wen-jun. Expression and Significance of BRAF and Its Signal Pathway in Papillary Thyroid Cancer[J]. Practical Preventive Medicine, 2011, 18(8): 1397-1399 |
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| Authors: | PENG Si-dan ZOU Qiong-yan YI Wen-jun |
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| Affiliation: | PENG Si-dan,ZOU Qiong-yan,YI Wen-jun(Department of Operating Room,the Second Xiangya Hospital,Central South University,Changsha 410011,Hunan,China) |
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| Abstract: | Objective To investigate the association and mechanism between the occurrence of papillary thyroid cancer and activity of BRAF,MEK/ERK signal pathway.Methods The clinical data and specimens about 73 cases of papillary thyroid cancer and 16 cases of thyroma were collected.Then we detected the expression of RAS,BRAF,MEK and ERK protein in all tumor specimens and benign thyroid tissues using immunohistochemistry.Results The expression of RAS,BRAF,pMEK and pERK protein in thyroid cancer tissues was significantl... |
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| Keywords: | BRAF RAS |
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