| 高效液相色谱法测定对乙酰氨基酚颗粒的溶出度 |
| |
| 引用本文： | 邵超. 高效液相色谱法测定对乙酰氨基酚颗粒的溶出度[J]. 海峡药学, 2011, 23(7): 76-77 |
| |
| 作者姓名： | 邵超 |
| |
| 作者单位： | 安徽阜阳市食品药品检验所,阜阳,236015 |
| |
| 摘 要： | 目的建立对乙酰氨基酚颗粒溶出度的高效液相测定方法。方法色谱柱为Waters C18柱（4．6mm×150mm，5μm），流动相为磷酸盐缓冲液（pH4．5）-甲醇（80：20），流速为1．0mL·min^-1，检测波长为254nm，柱温为30℃。结果对乙酰氨基酚在0．05-0．40mg·mL^-1浓度范围内呈良好线性关系（r=1．0），平均回收率为99．9％（n=9），RSD为0．27％。结论该方法准确、可靠，与标准法比较，结果较为满意，可用于对乙酰氨基酚颗粒的溶出度测定。
|
| 关 键 词： | 高效液相色谱法 溶出度 对乙酰氨基酚颗粒 |
Dissolution determination of paracetamol granules by HPLC |
| |
| SHAO Chao. Dissolution determination of paracetamol granules by HPLC[J]. Strait Pharmaceutical Journal, 2011, 23(7): 76-77 |
| |
| Authors: | SHAO Chao |
| |
| Affiliation: | SHAO Chao(Anhui Fuyang Institute for Food and Drug Control,fuyang 236015,China) |
| |
| Abstract: | OBJECTIVE To establish a HPLC method for dissolution of Paracetamol Granules.METHODS Waters C18 column(4.6mm×150mm,5μm)was used with a mobile phase composed of phosphate bufering solution(pH4.5)-methanol(80∶20)at the flow rate of 1.0mL·min-1,the detection wavelength was 254 nm and the temperature of the column Was 30℃.RESULTS The calibration curve of paracetamol was linear in the range of 0.05～0.40mg·mL-1,r=1.0.the average recovery rate Was 99.9% with a RSD of 0.27%(n=9).CONCLUSION This method is accurate,realiable and can be used for the of dissolution Paracetamol Granules. |
| |
| Keywords: | HPLC Dissolution Paracetamo1 Granules |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
