| 老年2型糖尿病患者血清炎症因子水平及其与大血管病变的相关性 |
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| 引用本文： | 洪旭,陈海平,于恒池.老年2型糖尿病患者血清炎症因子水平及其与大血管病变的相关性[J].中华糖尿病杂志,2011,19(8):571-574. |
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| 作者姓名： | 洪旭 陈海平 于恒池 |
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| 作者单位： | 洪旭,于恒池,HONG Xu,CHEN Hai-ping(首都医科大学附属北京友谊医院内分泌科,北京,100050);陈海平,CHEN Shu-jun(首都医科大学附属北京友谊医院老年病科,北京,100050) |
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| 摘 要： | 目的观察2型糖尿病患者血清炎症因子水平的变化，探讨炎症因子对2型糖尿病尤其老年患者合并心脑血管病变的影响。方法103例2型糖尿病患者按年龄及是否合并心脑血管病变分别分组。用自动生化分析仪测定所有患者血清高敏C反应蛋白（hsC-RP）、FBG、HbA1c、TC、TG、LDL-C水平，用ELISA方法测定血清白介素6（IL-6）和肿瘤坏死因子α（TNF-α）水平。结果（1）2型糖尿病患者年龄≥65岁者，血清hsC-RP、TNF-α、IL-6水平均高于年龄〈65岁者（P〈0．01）。（2）合并心脑血管病变者，血清hsC-RP水平较高于无心脑血管病变者（P〈0．05）。年龄≥65岁中合并心脑血管病变者，血清hsC-RP水平高于无心脑血管病变者（P〈0．05）。（3）血清hsC-RP水平与年龄和血清TG水平呈正相关（r=0．257，P〈0．01；r=0．220，P〈0．01）。影响hsC-RP的因素主要为年龄，回归方程为y（hsC-RP）=2．407＋0．100年龄。（4）2型糖尿病中≥65岁者合并心脑血管病变的发生率高于〈65岁者（P〈0．01）。结论hsC-RP与大血管病变相关，但IL-6和TNF-α与大血管病变无明显相关性；年龄增长是血清hsC-RP水平升高的主要影响因素。
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| 关 键 词： | 糖尿病 2型 心脑血管病变 高敏C反应蛋白 肿瘤坏死因子α 白介素6 |
The level of the serum inflammatory factors and their relationship with cardiocerebral vascular diseases in elderly patients with type 2 diabetes mellitus |
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| HONG Xu,CHEN Shu-jun,CHEN Hai-ping.The level of the serum inflammatory factors and their relationship with cardiocerebral vascular diseases in elderly patients with type 2 diabetes mellitus[J].CHINESE JOURNAL OF DIABETES MELLITUS,2011,19(8):571-574. |
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| Authors: | HONG Xu CHEN Shu-jun CHEN Hai-ping |
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| Institution: | HONG Xu, CHEN Shu-jun, CHEN Hal-ping. Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University , Beijing 100050 ,China |
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| Abstract: | Objective To investigate the serum levels of the inflammatory factors and their relationship with cardiocerebral vascular disease in type 2 diabetes mellitus. Methods The 103 patients with type 2 diabetes mellitus were divided into groups with and without cardiocerebral vascular disease and groups at age of 〈65 and ≥65 years. We detected the levels of serum hsC-RP, fasting blood glucose （FBG）, glycosylated hemoglobin （GHbA1c）, cholesterol total （TC）, triglyceride （TG）, low density lipoprotein-C（LDL-C）, serum TNF-α and IL-6. Results （1）The levels of serum hsC-RP, TNF-α and IL-6 were higher in patients of age≥65 years than of aged 65 years （P = 0. 003, P = 0. 001, P= 0. 007）. （2）The level of serum hsC-RP was higher in patients with cardiocerebral vascular disease （CCVD） than without CCVD（P=0. 015）. The level of serum hsC-RP was higher in patients with CCVD and at age of 65 years than in patients without CCVD（P=0. 040）. （3）Serum hsC-RP was positively correlated with age and serum TG（r=0. 257,P=0. 000;r=0. 220,P=0. 003）. The influencing factor for hsC-RP was age. （4）The incidence rate of CCVD in type 2 diabetes mellitus patients at age≥65 years was higher than patients at age〈（65 years （P = 0. 000）. Conclusion The serum hsC-RP is positively correlated with cardiocerebral vascular disease in T2DM, but IL-6 and TNF-α are not significantly associated with CCVD. And age is a main influencing factor for hsC-RP. |
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| Keywords: | Diabetes mellitus type 2 Cardiocerebral vascular disease CRP TNF-α IL-6 |
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