代谢综合征与非代谢综合征人群不同血脂成分对2型糖尿病发病风险的影响 |
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引用本文: | 陈冯梅,郭志荣,胡晓抒,武鸣,周慧.代谢综合征与非代谢综合征人群不同血脂成分对2型糖尿病发病风险的影响[J].中华糖尿病杂志,2011,19(8):565-567. |
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作者姓名: | 陈冯梅 郭志荣 胡晓抒 武鸣 周慧 |
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作者单位: | 陈冯梅(苏州卫生职业技术学院,215009);郭志荣(苏州大学);胡晓抒(江苏省卫生厅);武鸣(江苏省疾病预防与控制中心);周慧(苏州工业园区疾病预防与控制中心) |
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摘 要: | 目的通过前瞻性研究比较non-HDL-C、LDL-C在代谢综合征(MS)人群、非MS人群中与2型糖尿病(T2DM)发病的关系。方法将各血脂指标按水平三等分,以不患MS且血脂水平处于第一等分组的人群为对照组,比较MS、非MS人群各血脂水平与T2DM发病的关系。结果MS人群的血脂水平明显高于非MS人群。非MS人群中,TG、non-HDL-C、LDL-C水平在第三等分组时发生T2DM的风险最高。MS人群发生T2DM的风险均高于同血脂水平的非MS人群,但第三等分组发生T2DM的相对危险度(RR值)并没有增加。结论MS人群发生T2DM的风险高于非MS人群,但其发生T2DM的风险并没有随血脂水平的增高而增加。而非MS人群中,non-HDL-C、LDL-C在第三等分组发生T2DM的风险最高,且non-HDL-C的预测作用强于LDL-C。
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关 键 词: | 代谢综合征 糖尿病 2型 非高密度脂蛋白胆固醇 |
The effects of the different blood lipid components on the T2DM occurrence in metabolic syndrome(MS) versus non-MS patients |
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Institution: | CHEN Feng-mei, GUO Zhi-rong, HU Xiao-shu, et al. Suzhou Medical Technology College, Suzhou 215009, China |
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Abstract: | Objective The effects of the different blood lipid components on the T2DM occurrence in metabolic syndrome (MS) versus non-MS patients. Methods The risk ratio (RR) of type 2 diabetes occurrence was assessed based on different blood lipid componet effects in MS versus non-MS patients. Results Patients with MS had a higher T2DM RR than those without MS. In a multivariate model, T2DM risk in MS population didn't increase with increasing lipid. While in non-MS population, the third trisection of non-HDL-C, LDL-C had the highest RRs of 1. 691.06-2.68] in non-HDL-C of the third trisection, and 1. 6411.02-2.63]in LDL-C of the third trisection (all P〈0.05). Conclusions Non-HDL is a stronger predictor for T2DM occurrence among the non-MS population than LDL, and it should be given more consideration in the clinical approach to risk reduction among non-MS populations. |
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Keywords: | Metabolic syndrome Diabetes mellitus type 2 Non-HDL cholesterol |
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