| 百草枯对斑马鱼的生理指标和胚胎发育影响 |
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| 引用本文： | 夏勇,郑云燕,宋燕华,徐彩菊,鹿伟,傅剑云.百草枯对斑马鱼的生理指标和胚胎发育影响[J].劳动医学,2011,28(5):271-276. |
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| 作者姓名： | 夏勇 郑云燕 宋燕华 徐彩菊 鹿伟 傅剑云 |
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| 作者单位： | 浙江省疾病预防控制中心毒理所,浙江,杭州,310051 |
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| 摘 要： | 目的]探讨百草枯(paraquat,PQ)对斑马鱼(zebrafish,Danio rerio)的生理指标和胚胎发育影响,并确定其最大未观察到有害作用浓度(NOAEC).方法]参照经济合作与发展组织(OECD)推荐的方法,采用百草枯急性暴露试验、亚急性暴露试验及胚胎发育毒性试验进行研究.斑马鱼及其胚胎通过水环境暴露...
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| 关 键 词： | 百草枯 斑马鱼 生理指标 胚胎发育 毒性评价 超氧化物歧化酶 乙酰胆碱酯酶 腺苷三磷酸酶 |
Effects of Paraquat on Physiological Indicators and Embryos Development of Zebrafish |
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| XIA Yong,ZHENG Yun-yan,SONG Yan-hua,XU Cai-ju,LU Wei,FU Jian-yun.Effects of Paraquat on Physiological Indicators and Embryos Development of Zebrafish[J].Journal of Labour Medicine,2011,28(5):271-276. |
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| Authors: | XIA Yong ZHENG Yun-yan SONG Yan-hua XU Cai-ju LU Wei FU Jian-yun |
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| Institution: | XIA Yong,ZHENG Yun-yan,SONG Yan-hua,XU Cai-ju,LU Wei,FU Jian-yun~*(Department of Toxicology,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China) |
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| Abstract: | Objective]To study the effect of paraquat(PQ)on zebrafish(Danio rerio)physiological indicators and its embryonic development with its no-observed-adverse-effect-concentration(NOAEC)were determined.Methods]According to the method recommended by Organization for Economic Co-operation and Development(OECD),the impact of PQ in zebrafish was evaluated with acute exposure test,subacute exposure test and zebrafish embryos developmental toxicity test.Results]Based on the results of probability unit-graphic calcu... |
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| Keywords: | paraquat zebrafish physiological indicators embryos development toxic assessment SOD AChE ATPase |
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