综合干预对住院精神分裂症患者生活质量及预后的影响

目的：探讨综合干预对住院精神分裂症患者生活质量及预后的影响。方法：将126例首发精神分裂症住院患者随机分为综合干预组(62例)和对照组(64例)，在利培酮治疗的同时，对干预组予以综合干预措施，观察时间为8周，出院后随访一年。用阴性、阳性症状评定量表(PANSS)、生活质量量表(WHO，QOL-100)和复发率进行评估。结果：一年末随访时两组对精神分裂症阴性、阳性症状及PANSS总分均有改善，但干预组明显优于对照组；病人的生活质量两组均有改善，但干预组在生活质量总评、心理领域、独立性领域及社会关系领域的改善显著好于对照组；干预组的复发率、再住院率明显低于对照组。结论：对首发精神分裂症患者开展院内综合干预措施，更能改善患者的生活质量，降低复发率，有利于患者重返社会。

Effect of Comprehensive Intervention on Quality of Life and Prognosis of Inpatients with Schizophrenia

Objective: To study the effect of comprehensive intervention on life quality and prognosis of inpatients with schizophrenia.Methods: 126 inpatients with first episode schizophrenia were randomly divided into intervention group (n=62) and control group (n=64). Apart from antipsychotic medication, the intervention group received psychosocial help for 8 weeks. Both groups were assessed after one year of discharge. The assessments included PANSS, WHO QOL-100, and records of the rates of relapse and readmission.Results:Compared with the records when discharged, both the intervention group and control group improved in the total score, negative score and positive score of PANSS in the follow-up, with intervention group having greater improvement than control. Same results were got in quality of life. The rates of relapse and readmission were lower in intervention group.Conclusions:Psychosocial help in hospital can benefit schizophrenic inpatients after their discharge.