| 人骨巨细胞瘤化疗药物体外实验作用的分析 |
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| 引用本文： | 王洪,杜靖远,罗怀灿,杨述华,刘国平. 人骨巨细胞瘤化疗药物体外实验作用的分析[J]. 华中科技大学学报(医学版), 1999, 0(1) |
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| 作者姓名： | 王洪 杜靖远 罗怀灿 杨述华 刘国平 |
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| 作者单位： | 同济医科大学附属协和医院骨科 |
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| 摘 要： | 用体外培养的骨巨细胞瘤细胞系为研究对象，采用四氮唑蓝（ＭＴＴ）分析法着重观察了６种骨肿瘤的常用化疗药物：氨甲喋啶（ＭＴＸ）、阿霉素（ＡＤＲ）、顺铂（ＣＤＤＰ）、长春新碱（ＶＣＲ）、盐酸氮芥（ＮＭ）、丝裂霉素（ＭＭＣ）对骨巨细胞瘤的体外药物作用模式。结果发现ＭＴＸ呈坪型；ＡＤＲ呈双相指数型；ＣＤＤＰ呈阈值指数型；ＶＣＲ呈简单指数型；ＮＭ呈阈值指数型；ＭＭＣ呈简单指数型。除ＭＴＸ对其无作用外，其余都对其有一定的细胞毒作用。因而认为临床上对浸润型骨巨细胞瘤可开展化学治疗
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| 关 键 词： | 骨巨细胞瘤；MTT分析；药物疗法；药物筛选试验；抗肿瘤 |
In Vitro Experiment of Chemotherapeutic Drugs for Human Giant Cell Tumor of Bone |
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| Wang Hong,Du Jingyuan,Luo Huaican et al. In Vitro Experiment of Chemotherapeutic Drugs for Human Giant Cell Tumor of Bone[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1999, 0(1) |
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| Authors: | Wang Hong Du Jingyuan Luo Huaican et al |
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| Affiliation: | Wang Hong,Du Jingyuan,Luo Huaican et al Department of Orthopaedics,Xiehe Hospital,Tongji Medical University Wuhan 430022 |
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| Abstract: | Using MTT(Tetrazolium) assay, the mode of effects on giant cell tumor of bone cell line cultured in vitro was investigated under 6 kinds of chemotherapeutic drugs: MTX,ADR,CDDP,VCR,NM,MMC It was found that MTX showed a platform type, ADR double direct index type, CDDP and NM limited value index type, VCR and MMC simple index type Apart from MTX, others had cytotoxicity to cell line of giant cell tumor of bone to some extent It was considered that invasive giant cell tumor of bone could be treated by chemotherapy clinically |
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| Keywords: | giant cell tumor of bone MTT assay chemotherapy drug screening test antitumor |
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