胃癌转移状态血液流变学变化与中医证型关系的临床研究

目的：探讨不同分期和中医证型的胃癌患者血液流变学变化与转移状态的关系。方法：观察６３例不同分期的胃癌患者的全血比粘度（高切、低切）、血浆比粘度、红细胞压积、血浆纤维蛋白原、血小板计数及其聚集率等血液流变学变化。结果：胃癌组的全血比粘度、血浆比粘度、血浆纤维蛋白原、血小板计数及聚集率等明显地健康人组（Ｐ〈０．０５，Ｐ〈０．０１）。无转移组（８例）全血比粘度、血浆比粘度等项与健康人组比较无显著变化（Ｐ

Clinical Study on Hemorrheologic Changes for Metastatic State of Gastric Cancer and Its Relationship with Syndrome-Type in Traditional Chinese Medicine

To explore the hemorrheologic changes of gastric cancer in various stages, and the relationship between different phases and Syndrome types. Methods: Sixty three gastric cancer patients and 30 healthy controls matching in sex and age were studied. According to the phases of tumor and the differentiation standards of deficiency and excess syndrome in TCM, the patients were divided into 6 groups: Non metastasis (NM), lymphnode metastasis (LM), distant metastasis (DM) groups, and Deficiency (D), Excess (E), mixed deficiency and excess (DE) groups. The hemorrheology criteria including whole blood viscosity (BV), plasma viscosity (PV), hematocrit (HCT), fibrinogen (Fib), platelet count (PC), platelet aggregation rate (PAR) were measured. Results: The value of BV, PV, Fib, PC and PAR in gastric cancer groups were higher significantly (P<0 05,P<0 01) than those in the healthy control group, but BV, PV in the LM and DM groups were higher than those in the healthy control group significantly (P<0 05), while difference between NM group and the healthy control group was insignificant (P>0 05). Hypercoagulability state presented in all the three Syndrome Type groups of gastric cancer patients, but the difference in some criteria between D and E group were significant (P<0 05, P<0.01); and DE groups was greatly higher than D and E groups in high shear BV, Fib and PC (P<0 05,P<0.01). Conclusion: The value of BV, PV Fib, PC and PAR could be regarded as good referential parameters in reflecting the condition of evil excess.