A comparison of sporozoite transport after homologous and heterologous challenge in chickens immunized with the Guelph strain or the Florida strain of Eimeria maxima |
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Authors: | Savannah E Beattie M A Fernando John R Barta |
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Institution: | (1) Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada Tel.: +1-519-8244120 Ext. 4632; Fax: +1-519-8245930; e-mail: mfernand@uoguelph.ca, CA |
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Abstract: | The two strains of Eimeria maxima, Guelph and Florida, used in this study were previously shown to only partially cross-protect immunologically with respect
to lesion scores, weight gains and feed conversions after heterologous challenge. In this paper, we provide evidence that
this partial lack of cross-protection is manifested at the level of sporozoite transport. In birds immunized and challenged
with the homologous strain, sporozoites accumulated in the lamina propria and were blocked from further movement into the
crypts by 72 h post-challenge, unlike the situation observed in naive birds. Fewer than 5% of sporozoites were found in the
crypts by 72 h post-challenge. In immunized birds challenged with the heterologous strain, fewer sporozoites reached the crypts
than in naive birds but at least four times as many sporozoites successfully migrated to the crypts, when compared with birds
challenged with the homologous strain. The degree of cross-protection afforded by the heterologous strain as measured by sporozoite
transport success was not equally reciprocal.
Received: 26 June 2000 / Accepted: 8 August 2000 |
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