Inflammation and immunosuppression in severe acute pancreatitis |
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| Authors: | Marja-Leena Kylnp Heikki Repo Pauli Antero Puolakkainen |
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| Affiliation: | 1. Department of Surgery, University of Helsinki, PL 340, 00029 HUS,Helsinki, Finland
2. Department of Bacteriology and Immunology,Haartman Institute, University of Helsinki, PL 340, 00029 HUS,Helsinki, Finland |
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| Abstract: | Acute pancreatitis(AP) is a common disease,which usually exists in its mild form.However,in a fifth of cases,the disease is severe,with local pancreatic complications or systemic organ dysfunction or both.Because the development of organ failure is the major cause of death in AP,early identification of patients likely to develop organ failure is important.AP is initiated by intracellular activation of pancreatic proenzymes and autodigestion of the pancreas.Destruction of the pancreatic parenchyma first indu... |
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| Keywords: | Acute pancreatitis organ failure Inflammatory response Immunosuppression Coagulation |
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