| 自发性高血压大鼠左心室癌基因c－myc的表达 |
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| 引用本文： | 陈松苍,陈达光,王华军,林应锵,包幼迪,晋学庆.自发性高血压大鼠左心室癌基因c－myc的表达[J].福建医科大学学报,1994(3). |
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| 作者姓名： | 陈松苍 陈达光 王华军 林应锵 包幼迪 晋学庆 |
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| 作者单位： | 福建医学院高血压研究室，福建医学院基因工程研究室 |
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| 摘 要： | 探讨在体情况下癌基因ｃ－ｍｙｃ与心肌肥厚的关系，研究已有心肌肥厚雄性４０周龄自发性高血压大鼠（ＳＨＲ）和年龄、性别相配的Ｗｉｓｔａｒ京都种（ＷＫＹ）大鼠左心室ｃ－ｍｙｃ基因表达变化。Ｎｏｒｔｈｅｒｎ杂交的结果显示ＳＨＲ左室肌ｃ－ｍｙｃ表达量明显比ＷＫＹ高。左室增强的ｃ－ｍｙｃ表达可能在ＳＨＲ左室肥厚形成中起重要作用。
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| 关 键 词： | 自发性高血压大鼠，左室肥厚，癌基因，c－myc |
Expression of Proto-oncogene c-myc in Left Ventricle of Spontaneously Hypertensive Rats |
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| Chen Songcang, Chen Daguang, Wang Huajun,et al.Expression of Proto-oncogene c-myc in Left Ventricle of Spontaneously Hypertensive Rats[J].Journal of Fujian Medical University,1994(3). |
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| Authors: | Chen Songcang Chen Daguang Wang Huajun |
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| Abstract: | To explore the relation between proto-oncogene c-myc expression in vivo and cardiac hypertrophy, we investigated the change of proto-oncogene c-myc expression in left ventricle spontaneously hypertensive rats (SHR) with ventricular hypertrophy at 40-week-old and sex,age-matched Wistar-kyoto (WKY) rats. The results by northern hybridization showed that the expression of c-myc in left ventricle in SHR was significantly higher than that in WKY.The enhanced c-myc expression in SHR heart may play an important role in the development of left hypertrophy. |
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| Keywords: | rats inbred SHR hypertrophy left ventricular proto-oncogene c-myc |
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