冠心病患者血脂和胆红素变化的研究

目的探讨血脂、胆红素与冠心病发生、发展的关系。方法随机抽取139例冠心病患者和118例健康者进行血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDI，C）、低密度脂蛋白胆固醇（LDL—C）及胆红素水平检测与对比分析。结果冠心病组患者TG、TC、LDL—C、TG／HDL-C、LDLC／HDL-C显著升高（P〈0．01），HDL-C、总胆红素（TBil）及间接胆红素（IBil）显著降低（P〈0．01），且与冠脉病变程度相关；但直接胆红素（DBil）水平无明显差异（P〉0．05）。结论血脂异常和胆红素水平降低与冠心病密切相关。早期干预有可能预防心血管事件的发生。

Study on serum levels of lipids and bilirubin in patients with coronary heart disease

Objective To investigate the relationship of the levels of serum lipids and bilirubin with occurrence and development of coronary heart disease (CHD). Methods 139 CHD patients and 118 healthy controls were involved in the study. The serum levels of triglyeride (TG), total cholester-ol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)and bilirubin were measured and compared. Results In CHD group, the levels of TG, TC, LDL-C,TG, HDL-C, LDL-C and HDL-C were significantly elevated, while the levels of HDL-C, total biliru-bin (Tbil) and indirect bilirubin (Ibil) were markedly declined. The changes were associated with the severity of coronary artery disease. There wasn't significant difference of direct bilirubin level between CHD group and healthy control group. Conclusion Blood lipid abnormality and declination of bilirubin level are closely associated with coronary heart disease. It is possible to prevent the occurrence of car-diovascular event by early intervention.