| 紫外光纤法过程监测头孢克肟5种固体剂型的体外溶出度 |
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| 引用本文： | 杨淑梅,姚军,脱鸣富,李新霞,陈坚. 紫外光纤法过程监测头孢克肟5种固体剂型的体外溶出度[J]. 中国现代应用药学, 2011, 28(9): 854-856 |
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| 作者姓名： | 杨淑梅 姚军 脱鸣富 李新霞 陈坚 |
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| 作者单位： | 新疆医科大学第五附属医院，乌鲁木齐 830011;新疆医科大学药学院，乌鲁木齐 830054;新疆医科大学药学院，乌鲁木齐 830054;新疆医科大学药学院，乌鲁木齐 830054;新疆医科大学药学院，乌鲁木齐 830054 |
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| 基金项目： | 十一五国家科技支撑计划重大项目(2006BAK03A16) |
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| 摘 要： | 目的建立紫外光纤监测头孢克肟5种固体剂型的溶出度的方法。方法采用美国药典中头孢克肟片溶出度测定方法,结合六通道光纤传感原位过程分析仪原位、在线监测头孢克肟5种不同固体制剂溶出度。结果原位光纤法测定头孢克肟固体制剂的溶出数据与美国药典方法对照无统计学意义。结论原位光纤法无需取液、稀释等手工操作,能实时监测药物溶出全过程,为药物内在质量的检测提供良好的手段。
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| 关 键 词： | 头孢克肟 溶出度 光纤原位过程分析 |
| 收稿时间： | 2010-05-31 |
UV Fiber-optical Process Monitoring for Dissolution Behavior of 5 Solid Dosage Forms of Cefixime |
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| YANG Shumei,YAO Jun,TUO Mingfu,LI Xinxia and CHEN Jian. UV Fiber-optical Process Monitoring for Dissolution Behavior of 5 Solid Dosage Forms of Cefixime[J]. The Chinese Journal of Modern Applied Pharmacy, 2011, 28(9): 854-856 |
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| Authors: | YANG Shumei YAO Jun TUO Mingfu LI Xinxia CHEN Jian |
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| Affiliation: | The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China;College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China;College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China;College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China |
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| Abstract: | OBJECTIVE To develop an UV fiber-optical process monitoring method for dissolution behavior of five solid dosage forms of cefixime. METHODS Using the six channel fiber optical chemical sensor linked with-dissolving apparatus the dissolution rate of cefixime dispersible tablets was monitored by dynamic multiplying factor to eliminate interference of excipient. RESULTS The dissolution results measured by the instrument have no significant difference compared with the USP30-NF25. CONCLUSION The method needs no sampling and dilution. It can monitor the drug dissolution real-time. |
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| Keywords: | cefixime dissolution rate fiber optical in situ process analysis |
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