高血压患者血清白细胞介素-18和C反应蛋白水平检测的临床意义

目的:研究检测高血压病患者血清白细胞介素-18(IL-18)和C反应蛋白(CRP)的临床意义。方法:选择168例高血压患者和58例健康体检者,以酶联免疫吸附试验(ELISA)法和免疫比浊法检测其血清IL-18和CRP水平,分析其与高血压的相关性和临床意义。结果:与正常对照组比较,高血压病(1~3级)各组血清IL-18(120.7±76.4)ng/L:(224.8±80.7)ng/L:(478.9±184.1)ng/L:(669.1±210.3)ng/L]、CRP(2.4±1.6)mg/L:(5.9±3.8)mg/L:(24.1±12.6)mg/L:(41.6±16.5)mg/L]水平均显著升高(P均0.01);且随高血压分级水平升高,血清IL-18及CRP水平均逐渐升高(P0.01)。结论:血清白细胞介素-18、C反应蛋白水平与高血压的发病及分级水平有关,其测定很有意义。

Clinical significance of detection of serum interleukin-18 and C-reactive protein levels in patients with essential hypertension

Objective：To study the clinical significance detected serum levels of interleukin-18（IL-18） and C-reactive protein（CRP） in patients with essential hypertension（EH）.Methods：A total of 168 EH patients and 58 healthy controls were enrolled in the study.Enzyme linked immunosorbent assay（ELISA） and immunoturbidimetry were applied to detect serum levels of IL-18 and CRP.Results：Compared with normal control group,serum levels of IL-18 （120.7±76.4） ng/L vs.（224.8±80.7） ng/L vs.（478.9±184.1） ng/L vs.（669.1±210.3） ng/L],CRP （2.4±1.6） mg/L vs.（5.9±3.8） mg/L vs.（24.1±12.6） mg/L vs.（41.6±16.5） mg/L] in each group of hypertension（1~3 stage groups）significantly increased（P〈0.01 all）.Serum levels of IL-18 and CRP gradually increased as the stage of hypertension increased（P〈0.01 all）.Conclusion：Serum levels of interleukin-18 and C-reactive protein are associated with hypertension and its stage,so its detection posseses important significance.