Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone |
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Authors: | Seifer, David B. Giudice, Linda C. Dsupin, Beth A. Haning, Ray V., Jr Frishman, Gary N. Burger, Henry G. |
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Affiliation: | 1Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Brown University School of Medicine, Women and Infants Hospital 101 Dudley Street, Providence, RI 02905 2Department of Obstetrics and Gynecology, Stanford University Medical Center Stanford, CA, USA 3Department of Obstetrics and Gynecology, Prince Henry's Institute of Medical Research, Monash Medical Center Victoria, Australia |
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Abstract: | We determined follicular fluid concentrations of insulin-likegrowth factor (IGF)-I, IGF-II and inhibin as a function of day3 serum follicle stimulating hormone (FSH) in 16 women undergoingfollicular fluid aspiration in preparation for in-vitro fertilizationand embryo transfer. Follicular fluid concentrations of IGF-Iand IGF-II were significantly less in the lowFSH group as compared to the high FSH group. Themean IGF-I concentration was 67.6 ng/ml [confidence intervals(CI) 51.692.5] in the low FSH group comparedto 87.1 ng/ml (CI 72.8104.2; P < 0.025) in the highFSH group. Mean IGF-II concentrations were 354.8 ng/ml (CI 297.8422.9)in the low FSH group compared to 489.8 ng/ml (CI384.6624.5; P < 0.05) in the high FSHgroup. Follicular fluid inhibin concentrations did not differbetween groups. These differences in follicular fluid IGF asa function of day 3 FSH may raise questions regarding the rolegrowth factors play in the physiological processes of the ageingfollicle. |
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Keywords: | follicular fluid/growth factors/ovarian reserve |
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