精神分裂症伴发抑郁症状及其临床特征

目的 了解急性期住院精神分裂症患者伴发抑郁症状的发生率、临床特征及其相关因素。方法 对符合CCMD-3诊断标准的精神分裂症患者75例，分别于入院3天内评定PA．NSS、HAMD、TESS量表。结果 急性期抑郁发生率为30．7％，抑郁组与非抑郁组性别、婚姻、文化、年龄无显著性差异，抑郁组平均住院次数、偏执型精神分裂症所占比例多于非抑郁组。治疗前汉密顿抑郁量表总分与阴性量表、思维障碍症状群、反应缺乏症状群负相关，与一般精神病理量表、抑郁症状群正相关。结论 精神分裂症抑郁症状急性期较常见、较严重，偏执型精神分裂症更易出现抑郁症状。

Schizophrenic depressive symptoms and their clinical characteristics

Objective: To investigate the prevalence, characteristics and correlates of depressive symptoms in acute episode schizophrenic patients. Methods: 75 acute episode patients, who met CCMD-3 criteria for schizophrenia, were enrolled in the study. PANSS, HAMD and TESS were used in the first three days after admission. Results: 30.7% of the schizophrenic patients in acute episode had depressive symptoms. There were no differences between the depression group and the non-depression group in gender, marriage, education (year), age, duration of illness (months), and family history of psychosis. The average times of admission and the proportion of paranoid schizophrenia in the depression group were more than those in the non-depression group. Within three days of admission, the HAMD scores were negatively correlated with negative sub-scale scores, thought disorder syndrome scores, lacking of reaction syndrome scores, and positively correlated with general psychopathology sub-scale scores, depression syndrome scores. Conclusion: Depressive symptoms in acute episode schizophrenic patients are more frequent and severe, and the paranoid schizophrenic patients are more likely to have depressive symptoms.