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纳洛酮治疗中重度新生儿缺氧缺血性脑病的疗效观察
引用本文:李翠英,马桂香.纳洛酮治疗中重度新生儿缺氧缺血性脑病的疗效观察[J].儿科药学杂志,2003,9(4):56-56,i002.
作者姓名:李翠英  马桂香
作者单位:宁夏石嘴山市第二人民医院,宁夏,石嘴山,753000
摘    要:目的:观察纳洛酮治疗中重度新生儿缺氧缺血性脑病(HIE)的疗效。方法:将68例HIE患儿分为治疗组36例和对照组32例,对照组常规综合治疗,治疗组在对照组基础上加用纳洛酮0.1mg/kg,连用2~3d,观察临床症状与体征的变化。结果:总有效率治疗组94.44%,对照组75.00%,两组比较有显著性差异(P<0.05)。结论:纳洛酮治疗中重度HIE疗效显著,未见明显副作用。

关 键 词:纳洛酮  β-内啡肽  新生儿  缺氧缺血性脑病
文章编号:1672-108X(2003)04-0056-02

Obeservation on efficacy of naloxone on neonates with hypoxic-ischemic encephalopathy
LI Cui-ying,MA Gui-xiang.Obeservation on efficacy of naloxone on neonates with hypoxic-ischemic encephalopathy[J].Journal of Pediatric Pharmacy,2003,9(4):56-56,i002.
Authors:LI Cui-ying  MA Gui-xiang
Abstract:Objective:Observe the effects of naloxone on neonates with hypoxic-ischemic encephalopathy(HIE).Method:The sixty eight patients with HIE were divided into naloxone treated group(36cases)and contral group(32cases),the former was give naloxone(0.1mg/kg)in two to three days besides the common treatment,clinical symptoms and signs were observed.Results:The total effective rate is94.44%in the treated group and75.00%in control group.The comparison between the two groups is significant different(P<0.05).Conclusions:That naloxone has marked effects on neonates with HIE,there is no side effect in treatment.
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