脑膜瘤雌、孕激素受体表达与临床病理和预后的关系

目的：探讨脑膜瘤雌、孕激素受体表达与临床病理和预后的关系。方法：采用SABC免疫组化方法检测56例脑膜瘤组织中雌、孕激素受体表达，分析其与临床病理和预后的关系。结果：所有56例脑膜瘤组织中雌激素表达均为阴性，孕激素表达阳性率为60．7％（34／56），其中良性脑膜瘤组织中孕激素表达阳性率（69．6％）显著高于非良性脑膜瘤组织（20．0％），P〈0．01。统计分析显示，脑膜瘤孕激素表达与患者性别、组织亚型、肿瘤部位、切除程度无明显相关，而与肿瘤复发有关，复发脑膜瘤孕激素表达阳性率17．6％显著低于无复发脑膜瘤79．5％，P〈0.01。结论：脑膜瘤与雌激素无关，孕激素表达与脑膜瘤病理性质度复发有关，可作为脑膜瘤预后判定度治疗的重要参考指标。

Expression of estrogen, progesterone receptor in meningiomas and the relationship with clinicopathology and prognosis

Objective To explore the expression of estrogen and progesterone receptor and the relationship with clinicopathology and prognosis in meningiomas.Methods The expression of estrogen and progesterone receptor was determined by immunohistochemical method in 56 cases of meningioma tissues.The relationship between progesterone receptor expression and clinicopathological characteristics and prognosis were studied.Results The expression of estrogen was negative in 56 cases of meningioma tissues.The expression rate of progesterone receptor was 60.7%,in which benign meningiomas had a significantly higher progesterone receptor expression rate(69.6%) compared with non-benign meningioma(20.0%)(P<0.05).Chi-square analysis of the results did not show any relationship between progesterone receptor expression and patient's sex,histological subtype,tumor site or extent of resection,but did show a relationship between tumor recurrence and progesterone receptor negativity.The recurrent meningiomas had significantly lower positive rates of progesterone receptor expression(17.6%) compared with non-recurrent meningioma(79.5%) in benign meningiomas(P<0.01).Conclusion It is suggested that estrogen expression be lost or reduced in meningiomas,whereas progesterone receptor positive expression be related to histological features and recurrence,which is a finding that has prognostic and therapeutic implications.