Acute, Distribution, and Subchronic Toxicological Studies of Succinate Tartrates |
| |
Authors: | PETERSEN, DEBORAH WISSINK POWERS, JOHN F. AARDEMA, MARILYN J. LEBOEUF, ROBERT A. SMITH, LAURENCE A. |
| |
Affiliation: | *Human Safely Section, Ivorydale Technical Center, The Procter and Gamble Company Cincinnati, Ohio 45217 Human and Environmental Safety Division, Miami Valley Laboratories, The Procter and Gamble Company Cincinnati, Ohio 45217 Products Chemistry and Analytical Section, Ivorydale Technical Center, The Procter and Gamble Company Cincinnati, Ohio 45217 Received September 2, 1988; accepted January 23, 1988 |
| |
Abstract: | The estimated single-dose oral toxicity (50% lethality) of succinatetartrates (ST) was 23 g/kg in rats. ST produced minimalto moderate dermal irritation but no evidence of systemic toxicityin a standard acute percutaneous toxicity test in rabbits. STwas not an eye irritant in a standard rabbit low-volume eyeirritation test ST was not genotoxic in a series of six genotoxicitytests. A 14-day oral gavage study in rats at a dose range of0.051.0 g ST/kg/day produced only gastric irritation.The no-observed-effect level (NOEL) for gastric irritation was0.1 g/kg for males and 0.05 g/kg for females. A 28-day percutaneoustoxicity study in rabbits produced minimal to moderate dermalirritation and no adverse systemic effects at a high dose of450 mg ST/kg/day. Single-dose absorption, distribution, andelimination (ADE) studies in male rats showed that 1015%of an oral dose and 13% of a dermal dose were absorbed.Approximately 98% of the orally administered ST was eliminatedas 14C in urine, feces, or expired CO2 after 72 hr. Approximately80% of the dermally absorbed 14C dose was eliminated in urine,feces, or expired CO2 after 72 hr. In conclusion, no adverseeffects were noted in acute toxicity, genotoxicity, or subchronictoxicity studies conducted with ST. |
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|