Breast cancer-associated metastasis is significantly increased in a model of autoimmune arthritis |
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Authors: | Lopamudra Das Roy Latha B Pathangey Teresa L Tinder Jorge L Schettini Helen E Gruber Pinku Mukherjee |
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Affiliation: | (1) Department of Immunology, Mayo Clinic School of Medicine, 13400 E. Shea Blvd, 85259 Scottsdale, Arizona, USA;(2) Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd, 28223 Charlotte, NC, USA;(3) Department of Orthopedic Surgery, Carolinas Medical Center, 1543 Garden Terrace, 28232 Charlotte, NC, USA |
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Abstract: | Introduction Sites of chronic inflammation are often associated with the establishment and growth of various malignancies including breast cancer. A common inflammatory condition in humans is autoimmune arthritis (AA) that causes inflammation and deformity of the joints. Other systemic effects associated with arthritis include increased cellular infiltration and inflammation of the lungs. Several studies have reported statistically significant risk ratios between AA and breast cancer. Despite this knowledge, available for a decade, it has never been questioned if the site of chronic inflammation linked to AA creates a milieu that attracts tumor cells to home and grow in the inflamed bones and lungs which are frequent sites of breast cancer metastasis. |
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