Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: pharmacological interventions. |
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| Authors: | E Masini S Bianchi F Gambassi B Palmerani A Pistelli L Carlomagno P F Mannaioni |
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| Affiliation: | Department of Preclinical and Clinical Pharmacology, University of Florence, Italy. |
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| Abstract: | Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions. |
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