The association between XPD Asp312Asn polymorphism and lung cancer risk: a meta-analysis including 16,949 subjects |
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Authors: | Jian Zhang Li-Xin Qiu Shiang-Jiin Leaw Xi-Chun Hu Jian-Hua Chang |
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Institution: | (1) Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China;(2) Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; |
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Abstract: | To derive a more precise estimation of the relationship between the xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism
and lung cancer risk, a meta-analysis was performed. PubMed, Medline, Embase, and Web of Science were searched. Crude ORs
with 95% CIs were used to assess the strength of association between the XPD Asp312Asn polymorphism and lung cancer risk.
The pooled ORs were performed with co-dominant model (Asp/Asn vs. Asp/Asp, Asn/Asn vs. Asp/Asp), dominant model (Asp/Asn + Asn/Asn
vs. Asp/Asp), and recessive model (Asn/Asn vs. Asp/Asp + Asp/Asn), respectively. A total of 18 studies including 7,552 cases
and 9,397 controls were involved in this meta-analysis. Overall, significantly elevated lung cancer risk was associated with
XPD Asn allele when all studies were pooled into the meta-analysis (Asn/Asn vs. Asp/Asp: OR = 1.158, 95% CI = 1.018–1.317;
recessive model: OR = 1.161, 95% CI = 1.029–1.311). In the subgroup analysis by ethnicity, significantly increased risks were
found for both Caucasians (Asn/Asn vs. Asp/Asp: OR = 1.164, 95% CI = 1.003–1.351; recessive model: OR = 1.169, 95% CI = 1.016–1.345)
and Asians (Asn/Asn vs. Asp/Asp: OR = 8.056, 95% CI = 2.420–26.817; recessive model: OR = 7.956, 95% CI = 2.391–26.477). When
stratified by study design, statistically significantly elevated risk was noted in hospital-based studies (Asn/Asn vs. Asp/Asp:
OR = 1.315, 95% CI = 1.110–1.558; recessive model: OR = 1.290, 95% CI = 1.099–1.513). In conclusion, this meta-analysis suggests
that the XPD Asn allele is a low-penetrant risk factor for developing lung cancer. |
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