2847例药物神经损害病例报告分析

目的对辽宁省2007年药物性神经损害病例报告进行分析，探讨药物神经损害发生的规律。方法采用回顾性分析方法，对2007年辽宁省药品不良反应监测中心收集到的2847份药物致神经系统损害的病例报告进行分析。结果引起神经损害的药物主要包括抗微生物药物（30．31％）、作用于循环系统的药物（15．81％）、作用于中枢神经系统的药物（15．24％）和中药（14．99％）；不良反应主要为头痛、头晕、憋气、潮红、眩晕、嗜睡、失眠等。结论重视药物对神经系统的损害，合理使用有神经毒性的药物。

Analysis of 2847 Reports of Drug Induced Nervous Damage

Objective By analyzing the situation of drug induced nervous damage in Liaoning province in 2007, and to explore regularity. Methods With retrospective case study, analyze 2 847 adverse drug reaction（ADR） reports of drug induced nervous damage in Liaoning province in 2007. Results Drug induced nervous damage including antimicrobials （30.31%）, Circulatory system drugs （15.81%）, Central nervous system drugs（15.24%） and Chinese Herb Medicine（14.99%）. Adverse events include headache,dizziness, breath holding, flushing,vertigo,somnolence,insomnia. Conclusion It is important to pay close attention to the druginduced nervous damage, to ensure the safe and rational use of drug.