中西医结合治疗与单纯西医治疗结直肠癌的疗效分析

目的:系统评价中西医结合与单纯西医治疗结直肠癌(Colorectal cancer,CRC)的疗效和不良反应。方法:计算机检索中国生物医学文献数据库、中国期刊网、万方数据库、重庆维普和灰色文献,并配合手工检索所有文献全文,由两位评价者分别对资料进行质量评价,用Revman 5.1进行Meta分析,主要对实体瘤近期疗效、生活质量、不良反应进行分析。结果:共纳入9个随机对照试验,目前资料的Meta分析结果显示:临床治疗有效率:异质性检验P=0.99,表明研究数据具有同质性,故采用固定效应模式。合并效应量OR=1.48,95%CI 1.01～2.08,P0.05(P=0.04),差异有统计学意义,表明中西医结合治疗大肠癌的近期疗效优于单纯西药;患者生存质量改善:OR=3.48,95%CI 2.17～5.58,P0.01(P0.00001),有显著差异,提示中西医结合治疗组患者生存质量显著优于单纯西药组;不良反应发生:①白细胞减少情况OR=0.31,95%CI 0.20～0.49,P0.01(P0.00001),有显著统计学意义,提示中西医结合治疗组出现血液学毒性显著低于单纯西药组;②神经毒性OR=0.49,95%CI 0.30～0.81,P0.01(P=0.005),提示中西医结合治疗组出现神经毒性显著低于单纯西药组。结论:中西医结合治疗大肠癌的疗效优于单纯西药。

Meta-analysis of Integration of Traditional and Western Medicine Treatment Versus Western Treatment in Patients with Colorectal Cancer

Objective:To compare the effect of integration of Traditional and Western Medicine with western medicine therapy for colorectal cancer.Methods:Relevant literatures were reviewed via database and assessed via randomized controlled trial(RCT) scale.All reviewed literatures were assessed via Jadad quality scale.Data statistical analysis were performed by RevMan5.1 software.Results:Clinical efficient:since test for heterogeneity:P=0.99,it indicates the data has homogeneity,so we use the fixed effect model.OR=1.48,95%CI 1.01~2.08,P<0.05(P=0.04).It means that integration of Traditional and Western Medicine treatment for colorectal cancer in improving clinical symptom has obvious advantages compared with western medicine.For evaluation of quality of life,OR=3.48,95%CI 2.17~5.58,P<0.01(P<0.00001).It means that integration of Traditional and Western Medicine treatment for colorectal cancer in improving quality of life has obvious advantages compared with western medicine.For the main toxicity:①occurrence of hematological toxicity:OR=0.31,95%CI 0.20~0.49,P<0.01(P<0.00001);②occurrence of Neurotoxicity:OR=0.49,95%CI 0.30~0.81,P<0.01(P=0.005).They mean that integration of Traditional and Western Medicine treatment for colorectal cancer in reducing toxicity has obvious advantages compared with western medicine.Conclusion:Integration treatment for colorectal cancer shows curative effect,and there are obvious advantages compared with western medicin.