| 养生保健1号对脂多糖致小鼠肝损伤的影响 |
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| 引用本文： | 钱妍,吴整军,陈利平,仝战旗,段冬梅,臧倩. 养生保健1号对脂多糖致小鼠肝损伤的影响[J]. 中华中医药学刊, 2012, 0(2): 276-277,453 |
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| 作者姓名： | 钱妍 吴整军 陈利平 仝战旗 段冬梅 臧倩 |
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| 作者单位： | 解放军总医院南楼临床中医针灸科 |
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| 基金项目： | 国家科技支撑计划资助项目(2009BAI86B04) |
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| 摘 要： | 目的:观察养生保健1号对脂多糖(LPS)诱导小鼠急性肝损伤的保护作用及其对小鼠细胞因子的影响。方法:腹腔注射LPS建立小鼠急性肝损伤模型,养生保健1号灌胃,观察肝脏组织形态变化及小鼠血浆中炎症细胞因子TNF-α和IL-6水平。结果:养生保健1号可明显改善LPS引起的小鼠肝组织病理损伤,降低LPS致小鼠血浆TNF-α和IL-6的升高水平(P0.05)。结论:养生保健1号对LPS致小鼠肝细胞损伤具有保护作用的作用,可能的机制与减少炎性细胞因子释放有关。
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| 关 键 词： | 肝损伤 细胞因子 养生保健1号 小鼠 |
Effect of Yangshengbaojian Decoction on LPS induced Liver Injury of Mice |
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| Affiliation: | QIAN Yan,WU Zheng-jun,CHEN Li-ping,TONG Zhan-qi,DUAN Dong-mei,ZHANG Qian(Department of Nanlou Traditional Chinese Medicine(TCM),The General Hospital of PLA,Beijing 100853,China) |
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| Abstract: | Objective:To observe the effect on LPS induced liver injury and changes of TNF-α and IL-6 of mice by Yangshengbaojian Decoction(YS1).Methods:To establish hepatic injury models by LPS injection,YS1 was given by intragastric administration,the changes of TNF-α and IL-6 of plasma and histopathology of liver were observed.Results:YS1 can improve liver pathological injury and reduce the levels of TNF-α and IL-6.Conclusion:YS1 can protect LPS induced liver injury in mice and the possible mechanism are related to cyctokines production. |
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| Keywords: | liver injury cyctokines production Yangshengbaojian Decoction mice |
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