| 中医“血分论治”对寻常型银屑病患者Th17细胞表达影响的研究 |
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| 引用本文： | 陈晋广,杨志波,朱明芳.中医“血分论治”对寻常型银屑病患者Th17细胞表达影响的研究[J].中华中医药学刊,2012(2):306-307. |
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| 作者姓名： | 陈晋广 杨志波 朱明芳 |
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| 作者单位： | 台州市立医院;湖南中医药大学附属第二医院 |
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| 基金项目： | 国家自然科学基金资助项目(30873273);浙江省医药卫生科技计划资助项目(2010KYB129) |
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| 摘 要： | 目的:从Th17细胞角度研究"血分论治"银屑病的作用机制。方法:选择32例寻常型银屑病患者(血热证组17例,血瘀证组15例),15例健康人为对照组,分别给予清热凉血方、益气活血方治疗。各组分别于治疗前后应用酶联免疫吸附方法(ELISA)检测患者外周血Th17相关细胞因子白细胞介素(IL)-17和IL-23的表达。结果:银屑病患者IL-17、IL-23表达水平明显高于对照组。中药治疗后,两组患者IL-17、IL-23表达水平均明显下降。结果:从"血分论治"寻常型银屑病可通过调节IL-17、IL-23水平发挥治疗作用。
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| 关 键 词： | 银屑病 从“血分论治” IL-17 IL-23 |
Experimental Study on Blood-Stage Treatment on Influencing IL-17 IL-23 in Patients with Psoriasis Vulgaris |
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| CHEN Jin-guang,YANG Zhi-bo,ZHU Ming-fang.Experimental Study on Blood-Stage Treatment on Influencing IL-17 IL-23 in Patients with Psoriasis Vulgaris[J].Chinese Archives of Traditional Chinese Medicine,2012(2):306-307. |
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| Authors: | CHEN Jin-guang YANG Zhi-bo ZHU Ming-fang |
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| Institution: | 1.Department of Dermatology,Taizhou Municipal Hospital,Taizhou 318000,Zhejiang,China; 2.Second Affiliated Hospital of Hunan Chinese Medical College,Changsha 410005,Hunan,China) |
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| Abstract: | Objective:To investigate the action mechanisma of blood-stage treatment influence on psoriasis vulgaris from Th17.Methods:32 patients were observed and 15 healthy people were enrolled as control.Th17-related plasma cytokine(IL-17、IL-23) concentrations were measured by enzyme-linked immunosorbent assay(ELISA) before and after treated by heat-clearing and blood-cooling decoction and qi-enriching and blood-activating decoction.Results:Th17-related cytokine(IL-17 and IL-23) markedly increased in psoriasis compared with controls.After herbal treatment,IL-17 and IL-23 expressions decreased.Conclusion:Blood-stage treatment works well on IL-17 and IL-23 expressions in patients with psoriasis vulgaris. |
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| Keywords: | psoriasis Blood-Stage Treatment IL-17 IL-23 |
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