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Effect of lysine vasopressin in depressed patients on mood and 24-hour rhythm of growth hormone, cortisol, melatonin and prolactin
Authors:J Zohar  D Drummer  E D Edelstein  N Kaiser  R H Belmaker  I Nir
Affiliation:1. Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel;2. Hebrew University-Hadassah Medical School, Jerusalem, Israel
Abstract:Lysine-8-vasopressin (LVP) for 10 days and in doses up to 13.5 LVP units did not significantly alter the Hamilton Depression Rating Scale scores of 12 severely depressed, treatment-resistant patients who were evaluated in a double-blind crossover study. The 24-h rhythms of melatonin, cortisol, growth hormone and prolactin appeared remarkably stable over the course of repeated measurement. LVP administration did not affect these 24-h rhythms.
Keywords:Lysine vasopressin  resistant depression  24-h rhythm  prolactin  cortisol  melatonin  growth hormone
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