粪肠球菌在牙髓根尖周病中致病机制及抗菌治疗的研究进展

粪肠球菌是近年来被广泛研究的牙髓根尖周病重要致病菌。大量研究表明,粪肠球菌在根管治疗后的持续或继发性感染根管中较高的检出率,与根管治疗失败密切相关。粪肠球菌在牙髓根尖周病中的致病性与其具有的致病能力及相关毒力因子有关,可直接侵袭宿主组织或通过诱导宿主免疫炎症反应,造成牙髓根尖周组织损伤和病变。粪肠球菌对常规的根管抗菌药物及消毒方法有较强的耐受力,难以将其从结构复杂的根管系统内彻底清除,如何对抗粪肠球菌感染成为目前牙髓根尖周病治疗研究中的重要方向之一。本文就粪肠球菌在牙髓根尖周病中的致病机制及对其治疗的研究进展作一综述。

Research progress on the pathogenesis and treatment of Enterococcus faecalis in pulp periapical disease

Enterococcus faecalis is an important pathogen in pulp periapical disease that has been widely studied in recent years.A large number of studies have shown that the high detection rate of Enterococcus faecalis in root canals with persistent or secondary infection after root canal therapy is closely related to the failure of root canal therapy.The presence of Enterococcus faecalis in periapical pulp disease is related to its pathogenicity and virulence factors.Enterococcus faecalis can directly invade host tissues or induce immune inflammation in host tissues,resulting in periapical pulp tissue damage and lesions.Enterococcus faecalis has a strong tolerance to conventional root canal antibiotics and disinfection methods and is difficult to completely remove from the complex root canal system.How to fight Enterococcus faecalis infection has become an important direction in the treatment of pulp periapical disease.This article reviews the pathogenic mechanism of Enterococcus faecalis infection in pulp periapical disease and the progress in its treatment.