A randomized,double-blind,placebo-controlled,multicenter clinical trial for efficacy and safety of traditional Chinese medicine combined with antibiotics in the treatment of bacterial pneumonia in children |
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| Authors: | Lina Wei Yina Guo Yutong Fei Lin Luo Caiwen Wang Xuejiao Wang Haihang Sun Liang Liu Jing Han Xiaoting Ren Bo Yao Lei Wang Yijie Wang Liping Sun |
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| Affiliation: | aFirst Affiliated Hospital to Changchun University of Chinese Medicine, Jilin;bChangchun University of Chinese Medicine, Changchun;cBeijing University of Chinese Medicine;dResearch Institute of China Academy of Chinese Medical Sciences, Beijing, China. |
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| Abstract: | Background:Pneumonia is the second leading cause of death in children worldwide after preterm birth and certification. Bacteria, viruses, mycoplasma, and other microorganisms are known to be the main causes of pneumonia, of which bacterial pathogenic factors account for 12.5% of cases. The invention and application of antibiotics have improved the prognosis of children with community-acquired bacterial pneumonia (CABP) to a certain extent, but with the emergence of antibiotic resistance worldwide, the mortality of children with CABP is still high. “Maxing Shigan Decoction” and “Qingfei Decoction” have significant efficacy in the treatment of CABP in children, but there is no standardized randomized controlled trial to systematically evaluate the outcomes.Methods:This study is a randomized, double-blind, placebo-controlled, multicenter clinical trial that will randomize 240 patients with CABP to group of Oral Maxing Shigan Decoction, group of Qingfei Decoction or group of placebos administered 3 times a day for 7 days. This study will observe a wide range of clinically relevant endpoints that have been used in clinical trials of pneumonia, including but not limited to clinical cure rate, antibiotic application days, complete antipyretic rate, complete antipyretic days, disease efficacy, traditional Chinese medicine syndrome effect, and antibiotic upgrade treatment rates. Safety will be assessed by monitoring for the incidence of adverse events during the study.Discussion:This clinical trial is the first to evaluate the efficacy and safety of “Maxing Shigan Decoction” and “Qingfei Decoction” in the treatment of children with CABP. The research results will provide a reference for future research design.Trial registration:Chinese Clinical Trial Registry, ChiCTR1900025354. Registered on 14th October 2019-Retrospectively registered, http://www.chictr.org.cn/. |
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| Keywords: | children community-acquired bacterial pneumonia herbal medicine Maxing Shigan Decoction Qingfei Decoction randomized controlled trial |
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