海洋微生物次级代谢产物抗炎作用研究进展

炎症作为机体抵抗有害刺激修复损伤组织的防御反应,参与多种疾病的发展进程,严重危害人类生命健康。而临床常用的抗炎药物有一定的不良反应,寻找一些高效、低毒的抗炎先导化合物仍是一个重要方向。海洋作为各类生物资源的宝库,由于海洋生态环境的特殊性(高压、高盐,低氧等),使得许多海洋生物在生命过程中产生大量具有特殊结构和抗炎活性的天然产物,成为炎症新药物研发的重要来源。本文总结了2016-2021年从放线菌、真菌、细菌三类海洋微生物中分离出的约73种天然产物,并对其在抑制炎症活性方面进行综述,以期望为今后的研究提供借鉴和启发。

Research on Anti-inflammatory Effects of Secondary Metabolites of Marine Microorganisms

Inflammation, as a defense response of the body to resist harmful stimuli and repair damaged tissues, is involved in the development of many diseases and seriously endangers human life and health. The commonly used anti-inflammatory drugs in clinic have some adverse reactions. It is still an important direction to discover some high-efficiency and low toxicity anti-inflammatory lead compounds. The ocean is a treasure house of various biological resources. Due to the particularity of the marine ecological environment (high pressure, high salt, low oxygen, etc.), many marine organisms produce a large number of natural products with special structures and anti-inflammatory activities during their life, becoming an important source of research and development of new inflammatory drugs. In this paper, about 73 natural products isolated from three categories of marine microorganisms, actinomycetes, fungi and bacteria, were summarized from 2016 to 2021, and their anti-inflammatory activities were discussed to provide reference and inspiration for future research.