血清CEA和CA199及CA724联合检测对胃癌诊断的临床意义

目的探讨血清CEA、CA199、CA724联合检测在胃癌诊断、病情监测及疗效观察中的价值。方法采用电化学发光技术检测30例正常对照组、40例良性胃病、60例胃癌患者血清CEA、CA199、CA724的含量,并对胃癌患者进行治疗前后3种肿瘤标志物的含量变化监测、随访。结果胃癌患者血清CEA、CA199、CA724的阳性检测率明显高于良性胃病及正常对照组,差异有显著性(P<0.01)。胃癌患者治疗后3种肿瘤标志物含量及阳性率较治疗前有明显下降,差异有显著性(P<0.01)。三者联合检测敏感性、准确性均显著提高(P<0.05)。结论血清CEA、CA199、CA724联合检测有助于提高胃癌诊断的敏感性,同时对疗效观察及术后检测有重要意义。

Clinical value of combined detection of serum CEA,CA199 and CA724 in patient with gastric cancer

ObjectiveTo study the value of combined detection of serum CEA,CA199 and CA724 in diagnosis,monitoring patient's condition and therapeutic effectiveness in patient with gastric cancer.MethodsSerum levels of CEA,CA199 and CA724 were measured by electrochemiluminescence assay in 30 healthy adults,forty patients with benign gastrosia and 60 patients with gastric cancer.After treatment,the levels of the three kinds of tumor marker in patient with gastric cancer were compared with those before treatment.Results The levels of three kinds of tumor marker in gastric cancer group were obviously higher than those in control group and benign gastrosia group(P<0.01). The serum levels of three kinds of tumor marker in patient with gastric cancer were significantly decreased after treatment (P<0.01).Both sensitivity and specificity of detection were improved when the combined detection of CEA,CA199 and CA724(P<0.05)was used.ConclusionThe combined detection of CEA,CA199 and CA724 can significantly improve the sensitivity and specificity of diagnosis of gastric cancer and also has a notable value in observing therapeutic effectiveness of gastric cancer.