| 竹黄颗粒剂II号对银屑病患者外周血单个核细胞转录因子T-bet/GATA3 mRNA表达的影响 |
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| 引用本文： | 陈晋广,任小丽. 竹黄颗粒剂II号对银屑病患者外周血单个核细胞转录因子T-bet/GATA3 mRNA表达的影响[J]. 中国麻风皮肤病杂志, 2006, 0(12) |
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| 作者姓名： | 陈晋广 任小丽 |
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| 作者单位： | 浙江省台州市立医院皮肤科 318000 |
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| 摘 要： | 目的:探讨竹黄颗粒剂II号对寻常型银屑病的作用机制。方法:36例寻常型银屑病患者,按随机数字表,分竹黄颗粒剂II号治疗组(竹黄组)19例与银屑灵冲剂治疗组(银屑组)17例,分别于治疗前、后用RT-PCR技术检测外周血单个核细胞转录因子T-bet/GATA3 mRNA的表达,并以15例正常人作为对照组。结果:治疗后T-bet/GATA3 mRNA表达均显著改变(P<0.05);其中竹黄组效果优于银屑组(P<0.01)。结论:竹黄颗粒剂II号治疗银屑病有效的机制可能是通过降低患者T-bet/GATA3 mRNA的表达。
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| 关 键 词： | 银屑病 竹黄颗粒剂 T-bet/GATA3 |
The effects of Zhuhuang granule No.II on the expression of peripheral blood mononuclear cells T-bet/GATA3 mRNA in psoriasis vulgaris |
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| Chen Jinguang,Ren Xiaoli. The effects of Zhuhuang granule No.II on the expression of peripheral blood mononuclear cells T-bet/GATA3 mRNA in psoriasis vulgaris[J]. China Journal of Leprosy and Skin Diseases, 2006, 0(12) |
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| Authors: | Chen Jinguang Ren Xiaoli |
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| Affiliation: | Chen Jinguang,Ren Xiaoli.Department of Dermatology,ZheJiang TaiZhou Municipal Hospital,Taizhou,318000 |
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| Abstract: | Objective: To evaluate the therapeutic mechanism of Zhuhuang Granule No.II(ZHG).Methods: Thirty-six patients with psoriasis vulgaris were randomly divided into two groups: 19 patients in ZHG group and 17 patients in Yin-Xie-Ling group.T-bet/GATA3 mRNA expression in peripheral blood mononuclear cells was measured by RT-PCR before and after treatment.Fifteen normal subjects were selected as control.Results: The level of T-bet/GATA3 in all cases in both Zhuhuang group and Yin-xie-ling group decreased significantly after treatment(P<0.05).The decrease in Zhuhuang group was more remarkable than that in Yin-xie-ling group(P<0.01).(Conclusion): Zhuhuang granule can decrease the expression of T-bet/GATA3,which may be the effective mechanism of ZHG in the treatment of psoriasis vulgaris. |
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| Keywords: | psoriasis Zhuhuang granule T-bet/GATA3 |
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