Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression |
| |
| Authors: | Masahiro Ito Masahiro Nakashima Gabit K Alipov Sumihiro Matsuzaki Akira Ohtsuru Hiroyuki Yano Shunichi Yamashita Ichiro Sekine |
| |
| Institution: | (1) Department of Pathology, Department of Cell Physiology, Atomic Disease Institute, Nagasaki University School of Medicine, 1-12-4 Sakamoto, 852 Nagasaki, Japan |
| |
| Abstract: | Parathyroid hormone-related peptide (PTHrP) is involved in cell proliferation in both neoplastic and non-neoplastic tissues.
We describe an autopsy case of gastric cancer in a patient who showed serum hypercalcemia and overexpression of PTHrP and
PTH/PTHrP receptor in the metastatic tumor cells. The primary gastric tumor was poorly differentiated adenocarcinoma, and
multiple metastases were present in the bone, multiple visceral organs, peritoneum, and lymph nodes. PTHrP and its mRNA were
detected only in the metastatic tumor cells, but not in primary gastric tumor. PTH/PTHrP receptor was also demonstrated immunohistologically
in metastatic tumor cells. This case suggests that the expression of PTHrP is related to tumor progression and the poor prognosis
in tumors associated with humoral hypercalcemia. |
| |
| Keywords: | PTHrP PTH/PTHrP receptor gastric cancer progression |
| 本文献已被 SpringerLink 等数据库收录！ |
|
