In serous ovarian neoplasms the frequency of Ki-ras mutations correlates with their malignant potential |
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Authors: | C. J. Haas Joachim Diebold Astrid Hirschmann Helmut Rohrbach Udo Löhrs |
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Affiliation: | Institute of Pathology, Ludwig-Maximilians-Universit?t, Munich, Germany, DE
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Abstract: | Ki-ras mutations by denaturing gradient gel electrophoresis (DGGE) and direct sequencing after microdissection. Point mutations at codon 12 were found in 7 of 20 tumours of low malignant potential (LMP) (35%) and in 2 of 6 well-differentiated carcinomas (33%). In contrast, no mutations were detected in the 11 poorly differentiated ovarian carcinoma samples or in the 7 serous cystadenomas. The frequency of Ki-ras mutations in serous ovarian tumours seems to correlate with the malignant potential of the neoplasms. The data favour the hypothesis of a de novo development of poorly differentiated ovarian carcinomas and do not support an evolution from LMP tumours or well-differentiated carcinomas. Received: 8 June 1998/Accepted: 8 October 1998 |
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Keywords: | Ki-ras mutations Serous ovarian neoplasms DGGE LMP tumours Carcinomas Cystadenomas |
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