958例城镇青少年非酒精性脂肪性肝病的患病特征及危险因素调查分析

目的研究城镇青少年非酒精性脂肪性肝病（NAFLD）的患病特征,分析青少年NAFLD患病的相关危险因素。方法采用随机分层整群抽样方法,对福州市10～19岁城镇青少年人群进行NAFLD相关问卷调查、体格检查、血生化和肝脏超声检查。结果福州市城镇青少年NAFLD患病率为4.6%（44/958）,男、女性NAFLD患病率分别为5.6%和3.2%,P〈0.01。超重及肥胖率随年龄增长而降低,NAFLD患病率随年龄增长而升高,18～19岁患病率最高（12.5%）。肥胖者NAFLD的检出率显著高于非肥胖者（P〈0.001）。多因素Logistic回归分析示BMI、腰臀比、脂肪肝家族史是城镇青少年NAFLD的危险因素。结论城镇青少年NAFLD患病率随年龄增长而升高,肥胖青少年伴发NAFLD较为普遍,BMI、腰臀比、脂肪肝家族史等因素与青少年NAFLD高度相关。

Diagnosis of the characteristics and risk factors of non-alcoholic fatty liver disease in 958 urban adolescent

Objective To study the prevalence and characteristics of non-alcoholic fatty liver disease（NAFLD） among urban adolescent.Methods Under the premise of informed consent,10 to 19 years old urban youth populations were included in th e study.A total of 958 urban adolescent were conducted questionnaire,physical examination,blood biochemistry and liver ultrasound inspection.Results The urb an adolescent overweight and obesity rates decreased with age.Urban adolescent NAFLD prevalence was 4.6%（44/958）,5.6% in male,3.2% in female.NAFLD prevalen ce increased with age and reached the highest（12.5%） among 18 to 19 years old a dolescent.The NAFLD rates in obese male and female were statistically higher th an that in non-obese male and female respectively（P0.001）.Multifactorial logis tic regression analysis showed that BMI,WHR and father or mother had history of fatty liver disease were the risk factors for NAFLD in urban adolescent.Conclu sions NAFLD prevalence of urban youth may increase with age and obese adolescent s are more commonly associated with NAFLD.BMI,WHR and family history of fatty liver disease are highly correlated with NAFLD of urban adolescent.