| 自聚肽纳米纤维支架承载骨髓源性心肌干细胞移植治疗心肌梗死的实验研究 |
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| 引用本文： | 崔晓军,谭玉珍,谢华,国海东,王存,张剑凯,郭金华. 自聚肽纳米纤维支架承载骨髓源性心肌干细胞移植治疗心肌梗死的实验研究[J]. 生物医学工程与临床, 2011, 15(4): 303-307,F0003 |
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| 作者姓名： | 崔晓军 谭玉珍 谢华 国海东 王存 张剑凯 郭金华 |
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| 作者单位： | 1. 广东医学院基础医学院,人体解剖学教研室,广东,东莞,524808
2. 复旦大学,上海医学院,人体解剖学与组织学胚胎学系,上海,200032 |
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| 基金项目： | 湛江市科技攻关计划项目 |
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| 摘 要： | 目的 探讨自聚肽纳米纤维支架承载骨髓源性心肌干细胞(MCSC)移植对大鼠心肌梗死后心功能恢复的影响,寻找一种更适合承载心肌干细胞治疗心肌梗死的可注射性生物材料.方法 通过单细胞克隆培养技术,从骨髓间充质干细胞中筛选具有心肌特异分化潜能的MCSC,固相合成自聚多肽.将雌性大鼠心肌梗死模型随机分为3组:对照组、MCSC移植...
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| 关 键 词： | 自聚肽纳米纤维支架 骨髓源性心肌干细胞 心肌梗死 移植 |
Self-assembled peptide nanofiber scaffold and marrow-derived cardiac stem cells transplantation in treatment of myocardial infarction |
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| CUI Xiao-jun,TAN Yu-zhen,XIE Hua,GUO Hai-dong,WANG Cun,ZHANG Jian-kai,GUO Jin-hua. Self-assembled peptide nanofiber scaffold and marrow-derived cardiac stem cells transplantation in treatment of myocardial infarction[J]. Biomedical Engineering and Clinical Medicine, 2011, 15(4): 303-307,F0003 |
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| Authors: | CUI Xiao-jun TAN Yu-zhen XIE Hua GUO Hai-dong WANG Cun ZHANG Jian-kai GUO Jin-hua |
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| Affiliation: | CUI Xiao-jun1,TAN Yu-zhen2,XIE Hua1,GUO Hai-dong2,WANG Cun2,ZHANG Jian-kai1,GUO Jin-hua1(1.Department of Anatomy,Guangdong Medical College School of Basic Medical,Dongguan 524808,Guangdong,China,2.Department of Human Anatomy with Embryology,Fudan University Shanghai Medical College,Shanghai 200032,China) |
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| Abstract: | Objective To explore the effect of the self-assembled peptide nanofiber scaffold(NFS) and marrow-derived cardiac stem cells(MCSC) transplantation on cardiac function after myocardial infarction(MI),and provide theoretical and experimental basis for new nano-material in clinical stem cell transplantation.Methods The MCSC were isolated from marrow mesenchymal stem cells with single-cell cloning culture,and identified by c-kit immunoflourence staining and Nkx 2.5 expression analysis.The self-assembled peptides... |
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| Keywords: | self-assemble peptide nanofibers marrow-derived cardiac stem cells myocardial infarction transplantation |
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