| 锰对大鼠空间学习记忆影响 |
| |
| 引用本文： | 肖忠新,牛丕业,李慧,李变兰,张淑华,高艾,田琳. 锰对大鼠空间学习记忆影响[J]. 中国公共卫生, 2010, 26(3) |
| |
| 作者姓名： | 肖忠新 牛丕业 李慧 李变兰 张淑华 高艾 田琳 |
| |
| 作者单位： | 1. 首都医科大学公共卫生与家庭医学学院劳动卫生与环境卫生学系,北京,100069
2. 首都医科大学基础医学院组织胚胎与解剖学系 |
| |
| 基金项目： | 国家自然科学基金，北京市优秀人才培养资助计划 |
| |
| 摘 要： | 目的探讨锰染毒大鼠空间学习记忆变化的规律。方法50只雄性大鼠适应性喂养1周后,随机分为5组,即生理盐水组(A组),Mn2+2.5,5,10,20 mg/kg(B、C、D、E组)。腹腔注射生理盐水或MnCl2溶液0.5 mL/d,共30 d。染毒结束后,采用Morris水迷宫试验测定大鼠潜伏期、总路程和穿台次数的变化。结果经多组比较的单因素方差分析,潜伏期、总路程、穿台次数各组均数间差异有统计学意义(F=7.813,P=0.000;F=8.190,P=0.000;F=3.461,P=0.000);与A组比较,B、C、D和E组潜伏期延长,差异有统计学意义(P0.05);与B组比较,D和E组潜伏期延长,差异有统计学意义(P0.05)。与A组比较,C、D和E组总路程延长,差异有统计学意义(P0.01);与B组比较,C、D和E组总路程延长,差异有统计学意义(P0.01)。与A组比较,B、C、D、E 4组穿台次数减少,差异有统计学意义(P0.05)。结论锰染毒可以引起大鼠空间学习记忆障碍。
|
| 关 键 词： | 锰 学习记忆 Morris水迷宫 |
Effect of manganese on spatial learning and memory ability in rats |
| |
| XIAO Zhong-xin,NIU Pi-ye,LI Hui,et al.. Effect of manganese on spatial learning and memory ability in rats[J]. Chinese Journal of Public Health, 2010, 26(3) |
| |
| Authors: | XIAO Zhong-xin NIU Pi-ye LI Hui et al. |
| |
| Affiliation: | XIAO Zhong-xin,NIU Pi-ye,LI Hui,et al.Department of Occupational Health , Environmental Medicine,School of Public Health , Family Medicine,Capital Medical University(Beijing 100069,China) |
| |
| Abstract: | Objective To study the effect of manganese(Mn) on long-term spatial learning and memory capability in rats.Methods Fifty male Sprague Dawley rats were randomly assigned to five groups:normal saline(Group A),Mn2+ 2.5mg/kg(Group B),Mn2+ 5mg/kg(Group C),Mn2+ 10mg/kg(Group D),and Mn2+ 20mg/kg(Group E).Each experimental group consisted of 10 animals.Morris water maze was used to examine the mean latency,pathlength,and the number of platform area crossing of the rats.Results In Morris water maze test,significant ... |
| |
| Keywords: | manganese learning memory Morris water maze |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
