分化抗原CD_7与小儿急性淋巴细胞白血病的临床关系

探讨表达CD7抗原的急性淋巴细胞白血病 (acutelymphoblasticleukemia ,ALL)患儿的临床特点及治疗反应。方法 :选择 1998 4～ 2 0 0 1 5在上海儿童医学中心和广州医学院第二附属医院住院治疗的小儿急性淋巴细胞白血病 (ALL)患者 82例。应用一组CD系列单克隆抗体随机检测了ALL患儿的表型 ,G显带进行染色体核型分析 ,治疗采用上海儿童医学中心常规化疗方案。将CD7+ 与CD7-的急淋进行对比。结果 :CD7+ 与CD7-急淋相比 ,年龄大 ,白细胞数高 ,肝脏明显增大 ,出现髓外白血病及严重并发症较多 ,第一疗程达CR人数少 ,达CR时间长 ,第一疗程内放弃治疗或死亡人数多 ,P170率高 (均为P <0 0 5 )。结论 :CD7+ ALL临床症状较重 ,治疗反应较差 ,预后欠佳

THE RELATIONSHIP BETWEEN DIFFERENTIATION ANTIGEN CD7 AND CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

To discuss the clinical characteristic pattern and response rate in childhood acute lymphoblastic leukemia (ALL) with CD7 expression, 82 children with ALL enrolled in the second Affiliated from April 1998 to May 2001 were selected. A panel of monoclonal antibodies was used to detect the immunophenotyping pattern in all these ALL patients. A banding method was used to analyze the karyotype pattern. The routine chemotherapeutic protocals in Shanghai Children Medical Center were used for treatment. The difference in clinical presentation and response rate in the ALL patients with CD7 expression were compared with the other subgroup without CD7 expression. Results:Showing that the clinical pattens in ALL patients with CD7 expression is significantly different from those without CD7 expression in age, high initial leukocyte counts, marked heapatomegaly, high incidence of extramedular in volvement and severe complication, as well as the number of cases and the time achieved complete remission (CR) was less and longer and the higher number of the cases giving up the treatment or passing away in the first course of treatment, the high rate of p170 expression ( P <0 05). Conclusion: The clinical presentation of CD7 + ALL was much severe, the response rate was less, their prognosis was poor.