大豆异黄酮对心血管保护作用的研究

目的雌激素具有心血管保护作用,但其不良效应限制了雌激素在防治心血管疾病方面的应用.寻求更有效、安全的雌激素替代品已成为心血管药物研究的热点.本文就植物性雌激素大豆异黄酮对心血管保护作用的研究现状进行综述.资料来源应用计算机检索Medline1993-01/2001-12的相关文章,检索词"isoflavones,atherosclerosis,vasodilation",并限定文章语言种类为English.同时计算机检索万方数据资源系统与中国期刊全文数据库1994-01/2002-02的文章,限定文章语言种类为中文,检索词"异黄酮类,动脉硬化,血管舒张".资料选择对资料进行初审,选取实验包括实验组和对照组的文献,筛除明显不随机实验的研究,对剩余的文献开始查找全文,进一步判断为随机对照实验.纳入标准为①随机对照实验,采用单盲,双盲或非盲法.②实验包含平行对照组.排除标准排除重复性实验研究.资料提炼共收集到31篇关于大豆异黄酮对心血管保护作用的随机和未随机实验文章,26个实验符合纳入标准.排除的5篇实验均为重复的同一研究.资料综合26个实验包括临床实验和动物实验,分别给予大豆异黄酮后采用在体或离体两种实验方法,观察大豆异黄酮对心血管的保护作用,并对此给予评价.以上两种方法各有优缺点,其中以离体实验进行观察的方法较常用.结论尚无充分证据证明大豆异黄酮防治绝经后妇女心血管疾病有肯定的效果,也无明确证明此方案的副作用.研究者应在如何掌握合适的量使异黄酮达到有效血浓度,在治疗效果有益无弊方面做更多的研究.

Cardiovascular protective effects of soy isoflavone

OBJECTIVE: Estrogen has cardiovascular protective effects while its adverse effects restrain its application in the therapy and prevention of cardiovascular diseases. To find a more effective and safer estrogen replacement becomes a hotspot in cardiovascular pharmaceutical researches. This paper summarized the current research situation on the cardiovascular protective effects of phytoestrogen, soy isoflavone.DATA SOURCES: Relative articles between January 1993 and December 2001 were searched by computer on Medline with the searching words of "isoflavones, atherosclerosis, vasodilation" in English, the language limitation of the articles. Simultaneously, articles between January 1994 and February 2002 were searched by computer on Wangfang Database and Chinese Journal Full Text Database with the searching words of "isoflavones,artherosclerosis, vasodilation(Chinese charcters)" in Chinese, the language limitation of the articles.DATA SELECTION: Literatures with experiments including study group and control group were selected from the data through preliminary screening to eliminate obvious non-randomized experimental studies. The full texts of the residual literatures were searched afterwards for the further judgment of ranincluded in the study. Exclusive criteria: repetitive experimental studies.DATA EXTRACTION: A total of 31 randomized or non-randomized experimental articles regarding the cardiovascular protective effects of soy isoflavone were collected, of which 26 experiments were in accordance with the inclusive criteria and the rest 5 articles were exclude due to repetition of same study.DATA SYNTHESIS: Twenty-six experiments including clinical experiments and animal experiments, which employed in vivo or in vitro two experimental methods after the application of soy isoflavone to observe and evaluate its cardiovascular protective effects. The above two methods had its own merits and shortcomings, of which in vitro experiment was a more common method for the observation.CONCLUSION: There is no adequate evidence that can prove the definite effects of soy isoflavone on the prevention and therapy of cardiovascular diseases in menopausal women, as well as its side effects. Researchers should do more researches on how to master the appropriate dose to make isoflavone reach effective blood concentration, and how to make the therapeutic effects become more beneficial.