IL-1对垂体促性腺细胞及甲状腺轴分泌功能的短期效应

本研究观察Ｗｉｓｔａｒ雄性大鼠腹腔注射ＩＬ－１后短期内（６ｈ内）血清ＬＨ、ＦＳＨ、ＰＲＬ、ＴＳＨ、Ｔ３和Ｔ４水平的变化。其结果表明，注射ＩＬ－１后血清ＬＨ和ＦＳＨ水平降低，血清ＰＲＬ水平增高；血清ＴＳＨ水平在注射后２ｈ内增高，４ｈ后恢复正常水平，而血清Ｔ３和Ｔ４水平降低。提示，ＩＬ－１在短期内可调节垂体促性腺细胞及甲状腺轴分泌功能。

Short term effects of IL-1 on secretive functions of pituitary gonadotropic cells and thyroid axis

In present study,we observed the changes of serum LH,FSH,PRL,TSH,T 3 and T 4 levels within 6 h after injecting IL-1 through i.p. in Wister male rate.The results showed that serum LH and FSH levels all decreased and serum PRL level increased within 6 h after injecting IL-1;serum TSH level increased within 2 h after injecting IL-1,recovered to control level 4 h later,while serum T 3 and T 4 levels all decreased within 6 h after injection.These results suggest that IL-1 might regulate the secretive functions of pituitary gonadotropic cells and thyroid axis within short term.