| 全反式维甲酸立体稳定脂质体的制备 |
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| 引用本文： | 赵蓉,朱家壁. 全反式维甲酸立体稳定脂质体的制备[J]. 药学学报, 2000, 35(12): 921-923 |
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| 作者姓名： | 赵蓉 朱家壁 |
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| 作者单位： | 中国药科大学中昆药剂研究所,江苏,南京,210009 |
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| 摘 要： | 目的 制备全反式维甲酸(RA)的立体稳定脂质体,初步研究其物理化学性质。方法 用DSC、1HNMR、激光粒径测定仪研究其微观结构、粒径大小及其分布,并用TEM拍摄。结果 制备的普通和立体稳定脂质体粒径分别约为0.35和0.42 μm,电镜下可观察到脂质体的立体稳定结构。结论 立体稳定脂质体中磷脂极性头部被吐温-80的聚氧乙烯基所覆盖,吐温-80掺入脂质膜,伸出的亲水性聚氧乙烯基提供了RA立体稳定脂质体的立体位阻。
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| 关 键 词： | 全反式维甲酸 立体稳定脂质体 物理化学性质 |
| 收稿时间： | 2000-04-03 |
| 修稿时间： | : |
PREPARATION OF STERICALLY STABILIZED LIPOSOMES CONTAINING ALL-TRANS RETINOIC ACID |
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| ZHAO Rong,ZHU Jia-bi. PREPARATION OF STERICALLY STABILIZED LIPOSOMES CONTAINING ALL-TRANS RETINOIC ACID[J]. Acta pharmaceutica Sinica, 2000, 35(12): 921-923 |
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| Authors: | ZHAO Rong ZHU Jia-bi |
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| Affiliation: | Zhongkun Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210009, China. |
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| Abstract: | AIM: To prepare sterically stabilized liposomes containing all-trans retinoic acid, and to study its physicochemical properties. METHODS: The microstructure, the particle size and its distribution was determined by DSC, 1HNMR and 90 Plus Particle Size Analyzer and a TEM photo was taken. RESULTS: The size of conventional liposomes and sterically stabilized liposomes were about 0.35 and 0.42 micron. The sterically stabilized structure can be confirmed by TEM photo. CONCLUSION: The stericallly stabilized liposomes containing all-trans retinoic acid can be prepared by combination of film-casting and freeze-drying. |
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| Keywords: | all trans retinoic acid sterically stabilized liposomes physicochemical properties |
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