舒心贴膏对麻醉开胸急性心肌梗塞犬血清中心肌酶和无机元素的影响

目的：观察舒心贴膏对麻醉开胸急性心肌梗塞犬血清中心肌酶和无机元素的影响。方法：杂种犬24只，随机分为空白对照组、阳性药组及实验组(包括舒心贴膏低剂量及高剂量组)。麻醉开胸犬结扎左冠状动脉前降支（LAD）制备急性心肌梗塞模型，测定心肌梗塞面积(MIS),血清天门冬氨酶转氨酶(AST)、肌酸磷酸激酶(CPK)、乳酸脱氢酶(LDH)活性，血清无机元素Cu、Zn、Ca和Mg含量。 结果：舒心贴膏低、高剂量组与空白对照组比较，能明显缩小MIS（P<0.05、P<0.01），降低血清CPK、AST、LDH活性（P<0.01）。舒心贴膏高剂量组与空白对照组比较血清Cu含量下降（P<0.01），Zn、Ca含量增加（P<0.05、P<0.01），Mg元素含量无明显变化；舒心贴膏低剂量组与空白对照组比较，血清Zn含量增加（P<0.05）。 结论：舒心贴膏能降低急性心肌梗塞犬体内心肌酶活性及调节血清无机元素含量的变化,对心肌缺血有明显的改善作用。

Influences of ShuXinTieGao on myocardium enzymes and inorganic elements in serum of anesthetic thoraco-opened dogs

Objective To observe the influences of ShuXinTieGao on the myocardium enzymes and inorganic elements in serum of anesthetic thoraco-opened dogs. Methods Twenty-four dogs were randomly divided into normal control group(Ⅰ),positive control group(Ⅱ),low dose of ShuXinTieGao group (0.042 g·kg -1 ,Ⅲ), and high dose of ShuXinTieGao group (0.083 g·kg -1 ,Ⅳ). The models with myocardial infarction were established through ligating the left anterior descending (LAD) coronary artery in anesthetic thoraco-opened dogs.The myocardial infarction scope (MIS), the activitives of AST, CK, and LDH in serum and the contents of Cu,Zn,Ca, and Mg in serum were determined in model dogs. Results Compared with control group,the MIS (P<0.05,P<0.01) and the activities of serum CK, AST,and LDH (P<0.01) were obviously decreased in groups Ⅲ and Ⅳ. Compared with control group, the content of serum inorganic element Cu of acute myocardial infarction dogs was decreased (P<0.01), while the contents of serum Zn and Ca were increased (P<0.05,P<0.01) and the content of serum Mg had no obvious change in group Ⅳ. The content of serum Zn was increased (P<0.05) compared with control group. Conclusion ShuXinTieGao can decrease the activities of the myocardium enzymes, regulate the contents of serum inorganic elements, and obviously improve the myocardial ischemia.