超声引导下经皮穿刺注射无水乙醇和氟尿嘧啶缓释剂治疗原发性肝癌53例

目的:探讨超声引导下经皮穿刺注射无水乙醇和5-氟尿嘧啶(5-Fu)缓释剂植入治疗原发性肝癌的可行性.方法:53例确诊为原发性肝癌的患者,通过观察患者肝功能及甲胎蛋白(AFP)、肿瘤大小变化、生存时间,分析超声引导下经皮穿刺注射无水乙醇和5-Fu缓释剂植入治疗原发性肝癌的疗效.结果:治疗后1个月和3个月与术前比较患者肝功能均明显改善,AFP均明显降低(P<0.01).治疗后3个月肿瘤消失5例,肿瘤缩小、轮廓不清45例.存活率＞6个月48例,＞1年34例,＞2年19例,＞3年8例.结论:超声引导下经皮穿刺注射无水乙醇和5-Fu缓释剂植入治疗原发性肝癌可取得较好效果,是一种安全有效的治疗方法.

Ultrasound-guided injection of ethanol and 5-Fu releaseformulation for treatment of primary hepatocellular carcinoma

Objective:To explore the feasibility of ethanol and 5-Fu release formulation injection under ultrasound-guidance in treatment of primary hepatocellular carcinoma.Methods:Fifty-three patients with primary liver cancer were studied retrospectively.The liver function,AFP,the tumor size and the survival time of the patients were observed.All the patients were treated by injecting ethanol and 5-Fu release formulation under the guidance of the ultrasound,and the effects were analyzed.Results:The liver function of the patients was improved and the value of AFP was reduced significantly after 1-3 months treatment compared with that before surgery(P<0.01).The tumor disappeared in 5 cases;tumor shrinkage and unclear contour were observed in 45 cases.The survival time was more than 6 months in 48 cases,more than 1 year in 34 cases,more than 2 years in 19 cases and more than 3 years in 8 cases.Conclusions:The therapeutic effect of injecting ethanol and 5-Fu release formulation under ultrasound-guidance is safe and effective for treatment of primary hepatocellular carcinoma.