SOCS3在皮肤黑素瘤中的表达及意义

目的:探讨SOCS3蛋白在皮肤黑素瘤和色素痣组织中的表达及意义。方法:应用免疫组织化学S-P法检测90例皮肤黑素瘤和43例色素痣组织中SOCS3、基质金属蛋白酶-2(matrix metalloproteinases,MMP-2)、MMP-9的表达情况,分析它们与患者临床病理特征的关系。结果:SOCS3蛋白在皮肤黑素瘤组织中的表达明显低于色素痣(分别为40.0%和60.5%,P0.05)。SOCS3低表达与肿瘤的厚度、侵袭深度、淋巴结转移均有一定关系(P0.05～P0.01);黑素瘤患者SOCS3表达阳性者的无复发生存和总生存率均较阴性者有显著性提高(P0.01)。此外,SOCS3表达与MMP-2和MMP-9(P0.01)蛋白表达均呈负相关关系(P0.05和P0.01)。结论:皮肤黑素瘤SOCS3表达与肿瘤生长、侵袭转移和预后密切相关,提示SOCS3蛋白可能在皮肤黑素瘤的侵袭生长过程中发挥了重要作用。

Expression and significance of suppressor of cytokine signaling 3 in human cutaneous melanoma

Objective:To study the expression and significance of suppressor of cytokine signaling 3(SOCS3) in cutaneous melanoma and nevus tissues. Methods:Immunohistochemical S-P method was used to detect the protein expression of SOCS3,matrix metalloproteinases-2(MMP-2)and MMP-9 of 90 cases with melanoma and 43 cases with nevus,and analysed the relation with the clinical and pathologic features of all patients. Results:The positive expression of SOCS3 in melanoma was significantly lower than that of nevus tissues(40% and 60.5% respectively,P<0.05),and.The low expression of SOCS3 was correlated to the diameters and invasive depth of tumors and metastasis of lymph node(P<0.05 to P<0.01).Compared with the cases with negative expression of SOCS3,the cases with melanoma with positive SOCS3 expression had significantly longer relapse-free survival and overall survival(P<0.01).SOCS3 expression was inversely correlated with the expression of MMP-2 and MMP-9(P<0.05 and P<0.01). Conclusions:The expression of SOCS3 was closely related to the tumor growth,invasion and metastasis,SOCS3 may play an important role on the invasive growth of human cutaneous melanoma.