乙型肝炎血清学指标与肝组织纤维化分期的相关性

目的:探讨乙型肝炎患者血清学指标与肝组织纤维化病理学分期的相关性。方法:对214例乙型肝炎患者肝组织活检后进行常规病理检查,同时检测其血清肝纤维化指标、生化指标、凝血指标。比较分析各项检测项目与肝组织纤维化分期之间的相关性。结果:肝纤维化病理学分期与透明质酸、层黏连蛋白、Ⅳ型胶原、Ⅲ型前胶原等血清学指标之间的差异均有统计学意义(P0.01)。结论:透明质酸、层粘连蛋白、Ⅳ型胶原、Ⅲ型前胶原等血清学检测项目的联合检测,可有效地辅助诊断乙型肝炎患者肝纤维化程度,并预测肝纤维化发展的趋势。

Analysis of correlation of serum markers and liver fibrosis stage in patients with chronic hepatitis B

Objective:To investigate the correlation of serum markers and liver fibrosis pathological stage in patients with chronic hepatitis B.Methods:The routine pathological examination of liver biopsy was tested in 214 cases of hepatitis B patients,the serum markers of liver fibrosis and liver function parameters,blood coagulation index and HBV-DNA level were also measured.The correlation of the test items and liver fibrosis stage was discussed.Results:There were statistical differences about hyaluronic acid,laminin,Ⅳ collagen,Ⅲ procollagen and other 10 test items with pathological stages of liver fibrosis(P<0.01).Conclusions:Hyaluronic acid,laminin,collagen Ⅳ,collagen Ⅲ and other serum test could be effective in diagnosis of hepatitis B patients with liver fibrosis,and they can predict the trend of liver fibrosis.