池州地区乙型肝炎病毒B、C基因型分布及临床意义

目的:了解池州地区乙型肝炎病毒(hepatitis B virus,HBV)B、C基因型的分布情况及其与临床指标的关系。方法:通过荧光定量PCR法测定116例乙型肝炎患者B、C基因型,并比较B、C基因型各项临床指标的关联性。结果:116例血清标本中,B基因型75例,C基因型39例,B/C混合型2例。不同基因型各临床指标差异无统计学意义(P0.05)。C基因型HBeAg阳性率为53.8%,B基因型为30.7%,差异有统计学意义(χ2=5.82,P0.05)。结论:池州地区HBV-DNA基因型分布以B型为主,C型次之;C基因型与较严重肝脏疾病的发生有关。

The distribution and clinical significance of hepatitis B virus B,C genotype in Chizhou district

Objective:To investigate the distribution of HBV B,C genotypes in Chizhou district and its clinical significance.Methods:The genotypes of 116 HBV-infected patients were determined by quantitative fluorescent PCR.The correlation of HBV genotype and clinical characteristics of patients were analyzed.Results:Among the 116 serum samples of HBV-infected patients,the genotype B and C were 75 cases and 39 cases respectively,the genotype B/C was 2 cases.There had no significant difference of clinical parameters between the different genotypes(P>0.05).The positive rate of HBeAg in genotype C group was 53.8%,which was higher than that in genotype B group(30.7%)(χ2=5.82,P<0.05).Conclusions:HBV genotype B is predominant in Chizhou district,following by genotype C.HBV genotype C is related to severity liver disease.