KAI1/CD82在喉鳞状细胞癌中的表达及其临床意义

目的:探讨喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)中KAI1/CD82的表达及其与临床病理参数的关系.方法:应用免疫组织化学EliVisionTM plus法检测83例LSCC组织和20例正常喉组织中KAI1/CD82的表达情况.结果:KAI1/CD82在正常喉组织和LSCC组织中的阳性率分别为90.0%和41.0%,差异有统计学意义(P<0.01),且LSCC组织分化程度高、无淋巴结转移、临床Ⅰ～Ⅱ期者的KAI1/CD82阳性率均高于组织分化程度低、有淋巴结转移、临床Ⅲ～Ⅳ期者(P<0.05～P<0.01),而不同性别、年龄、肿瘤大小及肿瘤位置的LSCC者阳性率差异均无统计学意义(P>0.05).结论:KAI1/CD82参与了LSCC组织的侵袭及转移,早期检测KAI1/CD82的表达可作为临床判断LSCC组织侵袭、转移的指标之一.

Expression and clinical significance of KAI1/CD82 in laryngeal squamous cell carcinoma

Objective:To investigate the expression of KAI1/CD82 in laryngeal squamous cell carcinoma(LSCC),and its correlation with clinic pathological parameters.Methods:The expression of KAI1/CD82 of 83 specimens of LSCC tissue and 20 specimens of normal laryngeal tissue were detected by immunohistochemistry.Results:The positive expression rates of KAI1/CD82 in LSCC tissue and normal laryngeal tissue were 41.0% and 90.0%,respectively,which had significant difference(P<0.01).The high differentiation and no lymph node metastasis of LSCC tissues were observed.The positive expression rates of KAI1/CD82 of cases with grade Ⅰ-Ⅱ were significantly higher than that of cases with grade Ⅲ-Ⅳ and lymph node metastasis(P<0.05 to P<0.01),while its expression was not associated with age,gender,diameter and location of tumor(P>0.05).Conclusions:The expression of KAI1/CD82 is closely related to the invasion and metastasis of LSCC,which can be an important indictor.