Expression of adhesion molecules and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions in HTLV-I-associated myelopathy |
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Authors: | F Umehara Shuji Izumo Motohiro Takeya Eiichi Sato Mitsuhiro Osame K Takahasi |
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Institution: | (1) Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka 8-35-1, Kagoshima, Japan Tel.: 81-992-75-5332; Fax: 81-992-65-7164, JP;(2) The Division of Molecular Pathology in Center for Chronic Viral Diseases, Kagoshima University School of Medicine, Kagoshima, Japan, JP;(3) The Second Department of Pathology, Kagoshima University School of Medicine, Kagoshima, Japan, JP;(4) The Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan, JP |
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Abstract: | Leukocyte adhesion molecules to endothelium plays an important role in the pathogenesis of inflammatory diseases, including
HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). To help define the role of adhesion molecules in HAM/TSP,
we studied the expression of lymphocyte function-associated antigen-1 (LFA-1), Mac-1, very late antigen-4 (VLA-4), Sialyl
Lewisx (SLex), intercelluar adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), endothelial leukocyte adhesion
molecule-1 (ELAM-1) and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions of HAM/TSP. The results indicate
that spinal cord lesions of HAM/TSP have greater VCAM-1 expression on endothelium compared with those of controls. Infiltrating
mononuclear cells, especially perivascular lesions, expressed VLA-4. Although the expression of ICAM-1 in the spinal cords
was not distinctive between HAM/TSP and controls, infiltrating mononulcear cells in the spinal cords of HAM/TSP strongly expressed
LFA-1 and Mac-1. ELAM-1 was expressed on endothelium in the inactive-chronic lesions from three of five HAM/TSP, but was not
detectable in the spinal cords of controls. SLex reaction was detectable on occasional perivascular cells in the spinal cord
of HAM/TSP, but not in those of controls. MCP-1 was detectable on perivascular infiltrating cells and vascular endothelium
in active-chronic lesions. This study suggests that VLA-4/VCAM-1 interaction may play an important role for lymphocyte migration
into the central nervous system (CNS), and MCP-1 may also be involved in inflammatory cell recruitment to the CNS in HAM/TSP.
Received: 4 September 1995 / Revised, accepted: 23 October 1995 |
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Keywords: | Adhesion molecules HTLV-1-associated myopathy/tropical spastic paraparesis Monocyte chemoattractant protein-1 Vascular cell adhesion molecule-1 Very late antigen-4 |
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