阿立哌唑与氯氮平对精神分裂症患者治疗依从性的对照研究

目的：探讨阿立哌唑对精神分裂症患者治疗依从性的影响。方法：把符合中国精神障碍分类与诊断标准第三版精神分裂症的诊断标准的患者120名，随机分成两组，分别给予阿立哌唑、氯氮平治疗2月，于治疗前及后2周、4周、8周末，用简明精神病量表和副反应量表评定疗效及副反应情况。用t检验或x^2检验比较分析两者的治疗依从性。结果：两组于治疗8周末的疗效无显著性差异；其治疗依从性则阿立哌唑组显著高于氯氮平组。副反应明显少于氯氮平组。结论：阿立哌唑的副反应少，能显著提高患者的治疗依从性，从而明显降低精神分裂症的复发率，获得显著的社会、经济效益。

A Controlled Study on Compliance of Schizophrenia Treated with Aripirazole and Clozapine

Objective: To study the effect of aipirazol on compliance of schizophrenia patients.Methods: 120 schizophrenia patients according with CCMD-3 were randomly divided into two groups: group A were treated with aipirazol,and group B treated with clozapine.BPRS and TESS were administered to test effect and side effect.Results: The compliance were significantly higher and side effect were significantly lower in group A than group B(P<0.05).Conclusion: Aipirazol can elevate the compliance of schizophrenia so as to reduce its recurrence and gain notable social and economic effects.